| Title : Comparative gene identification-58\/alpha\/beta hydrolase domain 5: more than just an adipose triglyceride lipase activator? - Zierler_2014_Curr.Opin.Lipidol_25_102 |
| Author(s) : Zierler KA , Zechner R , Haemmerle G |
| Ref : Curr Opin Lipidol , 25 :102 , 2014 |
| Abstract : PURPOSE OF REVIEW: Comparative gene identification-58 (CGI-58) is a lipid droplet-associated protein that controls intracellular triglyceride levels by its ability to activate adipose triglyceride lipase (ATGL). Additionally, CGI-58 was described to exhibit lysophosphatidic acid acyl transferase (LPAAT) activity. This review focuses on the significance of CGI-58 in energy metabolism in adipose and nonadipose tissue. RECENT FINDINGS: Recent studies with transgenic and CGI-58-deficient mouse strains underscored the importance of CGI-58 as a regulator of intracellular energy homeostasis by modulating ATGL-driven triglyceride hydrolysis. In accordance with this function, mice and humans that lack CGI-58 accumulate triglyceride in multiple tissues. Additionally, CGI-58-deficient mice develop an ATGL-independent severe skin barrier defect and die soon after birth. Although the premature death prevented a phenotypical characterization of adult global CGI-58 knockout mice, the characterization of mice with tissue-specific CGI-58 deficiency revealed new insights into its role in neutral lipid and energy metabolism. Concerning the ATGL-independent function of CGI-58, a recently identified LPAAT activity for CGI-58 was shown to be involved in the generation of signaling molecules regulating inflammatory processes and insulin action. SUMMARY: Although the function of CGI-58 in the catabolism of cellular triglyceride depots via ATGL is well established, further studies are required to consolidate the function of CGI-58 as LPAAT and to clarify the involvement of CGI-58 in the metabolism of skin lipids. |
| ESTHER : Zierler_2014_Curr.Opin.Lipidol_25_102 |
| PubMedSearch : Zierler_2014_Curr.Opin.Lipidol_25_102 |
| PubMedID: 24565921 |
Zierler KA, Zechner R, Haemmerle G (2014)
Comparative gene identification-58\/alpha\/beta hydrolase domain 5: more than just an adipose triglyceride lipase activator?
Curr Opin Lipidol
25 :102
Zierler KA, Zechner R, Haemmerle G (2014)
Curr Opin Lipidol
25 :102