| Title : Alpha\/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase - Stoelting_2009_Biochem.Biophys.Res.Commun_379_81 |
| Author(s) : Stoelting M , Geyer M , Reuter S , Reichelt R , Bek MJ , Pavenstadt H |
| Ref : Biochemical & Biophysical Research Communications , 379 :81 , 2009 |
| Abstract : Renal dopamine receptors have been shown to play a critical role in ROS-dependent hypertension. D5 dopamine receptor deficient (D5-/-) mice are hypertensive and have increased systemic oxidative stress which is manifested in the kidney and the brain. To further investigate the underlying mechanisms of hypertension in D5-/- mice, we used RNA arrays to compare mRNA levels of kidneys from wildtype and D5-/- mice. Our data show, that the mRNA level of alpha/beta hydrolase 1 (ABHD1) is significantly upregulated in D5-/- mice. Additionally, overexpression of ABHD1 in a new established renal proximal tubule cell line reduced the amount of O(2)(-) produced by the NADPH oxidase. Therefore the upregulation of ABHD1 in D5-/- mice could be an answer to the increased oxidative stress. While oxidative stress is an important factor for the development of hypertension, ABHD1 could play a protective role in the pathogenesis of hypertension. |
| ESTHER : Stoelting_2009_Biochem.Biophys.Res.Commun_379_81 |
| PubMedSearch : Stoelting_2009_Biochem.Biophys.Res.Commun_379_81 |
| PubMedID: 19073140 |
| Gene_locus related to this paper: human-ABHD1 , mouse-abhd1 |
| Gene_locus related to this paper: human-ABHD1 , mouse-abhd1 |
Stoelting M, Geyer M, Reuter S, Reichelt R, Bek MJ, Pavenstadt H (2009)
Alpha\/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase
Biochemical & Biophysical Research Communications
379 :81
Stoelting M, Geyer M, Reuter S, Reichelt R, Bek MJ, Pavenstadt H (2009)
Biochemical & Biophysical Research Communications
379 :81