We studied acetylcholinesterase (AChE) effects on glutamate receptors (GluR) in rat brain sections, synaptosomal membranes and cultured hippocampal neurones. A selective potentiation of AMPA receptors (AMPAR) binding in AMPAR-enriched layers undergoing synaptogenesis plus an increased surface expression of synaptic clusters of GluR1, GluR2, and SV2a was found. Thus, the AMPAR synaptic recruitment induced by AChE, could be a molecular mechanism underlying its non-classical synaptogenic actions.
        
Related information
Citations formats
Olivera Bravo S, Henley J, Rodriguez-Ithurralde D (2005) Acetylcholinesterase effects on glutamate receptors Chemico-Biological Interactions157-158: 410-11