Title: Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases Kotsovolou S, Verger R, Kokotos G Ref: Org Lett, 4:2625, 2002 : PubMed
[reaction: see text] Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.
        
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Kotsovolou S, Verger R, Kokotos G (2002) Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases Org Lett4: 2625-8
Kotsovolou S, Verger R, Kokotos G (2002) Org Lett4: 2625-8