Paper Report for: Fournier_1993_Chem.Biol.Interact_87_233
Reference
Title: Drosophila acetylcholinesterase: mechanisms of resistance to organophosphates Fournier D, Mutero A, Pralavorio M, Bride JM Ref: Chemico-Biological Interactions, 87:233, 1993 : PubMed
Quantitative and qualitative changes of acetylcholinesterase can affect the sensitivity of insects to insecticides. First, the amount of acetylcholinesterase in the central nervous system is important in Drosophila melanogaster, flies which overexpress the enzyme are more resistant than wild-type flies. On the contrary, flies which express low levels of acetylcholinesterase are more susceptible. An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Second, resistance can also result from a qualitative modification of acetylcholinesterase. Four mutations have been identified in resistant strains: Phe115 to Ser, Ileu199 to Val, Gly303 to Ala and Phe368 to Tyr. Each of these mutations led to a different pattern of resistance and combinations between these mutations led to highly resistant enzymes.
        
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Fournier D, Mutero A, Pralavorio M, Bride JM (1993) Drosophila acetylcholinesterase: mechanisms of resistance to organophosphates Chemico-Biological Interactions87: 233-8
Fournier D, Mutero A, Pralavorio M, Bride JM (1993) Chemico-Biological Interactions87: 233-8