| Title : alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility - Fisette_2016_Cell.Rep_17_1217 |
| Author(s) : Fisette A , Tobin S , Decarie-Spain L , Bouyakdan K , Peyot ML , Madiraju SR , Prentki M , Fulton S , Alquier T |
| Ref : Cell Rep , 17 :1217 , 2016 |
| Abstract : alpha/beta-Hydrolase domain 6 (ABHD6) is a monoacylglycerol hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Although complete or peripheral ABHD6 loss of function is protective against diet-induced obesity and insulin resistance, the role of ABHD6 in the central control of energy balance is unknown. Using a viral-mediated knockout approach, targeted endocannabinoid measures, and pharmacology, we discovered that mice lacking ABHD6 from neurons of the ventromedial hypothalamus (VMHKO) have higher VMH 2-AG levels in conditions of endocannabinoid recruitment and fail to physiologically adapt to key metabolic challenges. VMHKO mice exhibited blunted fasting-induced feeding and reduced food intake, energy expenditure, and adaptive thermogenesis in response to cold exposure, high-fat feeding, and dieting (transition to a low-fat diet). Our findings identify ABHD6 as a regulator of the counter-regulatory responses to major metabolic shifts, including fasting, nutrient excess, cold, and dieting, thereby highlighting the importance of ABHD6 in the VMH in mediating energy metabolism flexibility. |
| ESTHER : Fisette_2016_Cell.Rep_17_1217 |
| PubMedSearch : Fisette_2016_Cell.Rep_17_1217 |
| PubMedID: 27783937 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
Fisette A, Tobin S, Decarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SR, Prentki M, Fulton S, Alquier T (2016)
alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility
Cell Rep
17 :1217
Fisette A, Tobin S, Decarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SR, Prentki M, Fulton S, Alquier T (2016)
Cell Rep
17 :1217