Since the amino acid sequences for several muscarinic and adrenergic receptors are known, an attempt was made to correlate side chain hydrophobicity surrounding the aspartate anionic groups with binding structure-activity relationships. No positive correlation was found, suggesting that secondary binding effects of head group substituents are non-local. Displacement of aspartate ionization is unlikely to be due to such neighbour effects.
        
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Burgen AS (1989) Some considerations of receptor specificity Trends in Pharmacological SciencesSuppl: 1-3
Burgen AS (1989) Trends in Pharmacological SciencesSuppl: 1-3