| Title : Critical roles for alpha\/beta hydrolase domain 5 (ABHD5)\/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond - Brown_2017_Biochim.Biophys.Acta_1862_1233 |
| Author(s) : Brown AL , Mark Brown J |
| Ref : Biochimica & Biophysica Acta , 1862 :1233 , 2017 |
| Abstract : Mutations in the gene encoding comparative gene identification 58 (CGI-58), also known as alpha beta hydrolase domain-containing 5 (ABHD5), cause neutral lipid storage disorder with ichthyosis (NLSDI). This inborn error in metabolism is characterized by ectopic accumulation of triacylglycerols (TAG) within cytoplasmic lipid droplets in multiple cell types. Studies over the past decade have clearly demonstrated that CGI-58 is a potent regulator of TAG hydrolysis in the disease-relevant cell types. However, despite the reproducible genetic link between CGI-58 mutations and TAG storage, the molecular mechanisms by which CGI-58 regulates TAG hydrolysis are still incompletely understood. It is clear that CGI-58 can regulate TAG hydrolysis by activating the major TAG hydrolase adipose triglyceride lipase (ATGL), yet CGI-58 can also regulate lipid metabolism via mechanisms that do not involve ATGL. This review highlights recent progress made in defining the physiologic and biochemical function of CGI-58, and its broader role in energy homeostasis. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink. |
| ESTHER : Brown_2017_Biochim.Biophys.Acta_1862_1233 |
| PubMedSearch : Brown_2017_Biochim.Biophys.Acta_1862_1233 |
| PubMedID: 28827091 |
| Gene_locus related to this paper: human-ABHD5 |
| Gene_locus related to this paper: human-ABHD5 |
Brown AL, Mark Brown J (2017)
Critical roles for alpha\/beta hydrolase domain 5 (ABHD5)\/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond
Biochimica & Biophysica Acta
1862 :1233
Brown AL, Mark Brown J (2017)
Biochimica & Biophysica Acta
1862 :1233