Gene Locus : mouse-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site R in BChE additional positive charge near the lip of the gorgereduces binding energy by 0.8 kcal Radic_1993_Biochemistry_32_12074 Radic_1994_J.Biol.Chem_269_11233
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site
Torpedo_number : 279
Kinetic Parameter : Acetylthiocholine_W286R_mouse-ACHE, BW284C51_W286R_mouse-ACHE, Propidium_W286R_mouse-ACHE, Decamethonium_W286R_mouse-ACHE, WT-fasciculin2_W286R_mouse-ACHE
News : No news
Comment : p.W286R Trp286Arg (p.W286R Trp286Arg in primary sequence with 28 amino-acids signal peptide)
| Title : Reversible inhibition of acetylcholinesterase and butyrylcholinesterase by 4,4'-bipyridine and by a coumarin derivative - Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| Author(s) : Simeon-Rudolf V , Kovarik Z , Radic Z , Reiner E |
| Ref : Chemico-Biological Interactions , 119-120 :119 , 1999 |
| Abstract : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| ESTHER : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| PubMedSearch : Simeon-Rudolf_1999_Chem.Biol.Interact_119-120_119 |
| PubMedID: 10421445 |
| Title : Site of fasciculin interaction with acetylcholinesterase - Radic_1994_J.Biol.Chem_269_11233 |
| Author(s) : Radic Z , Duran R , Vellom DC , Li Y , Cervenansky C , Taylor P |
| Ref : Journal of Biological Chemistry , 269 :11233 , 1994 |
| Abstract : Radic_1994_J.Biol.Chem_269_11233 |
| ESTHER : Radic_1994_J.Biol.Chem_269_11233 |
| PubMedSearch : Radic_1994_J.Biol.Chem_269_11233 |
| PubMedID: 8157652 |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : Radic_1993_Biochemistry_32_12074 |
| ESTHER : Radic_1993_Biochemistry_32_12074 |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |