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Mutation Report for: T284P/S287R/V288S_human-BCHE

T284P/S287R/V288S_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|T284P/S287R/V288S
Torpedo number|286//289//290//286,289,290
Summary|
Comment|p.T284P/S287R/V288S Thr284Pro/Ser287Arg/Val288Ser (p.T312P/S315R/V316S Thr312Pro/Ser315Arg/Val316Ser in primary sequence with 28 amino-acids signal peptide) Multiple amino acid substitutions in the acyl-binding loop 284-TPLSV-288 284-ThrProLeuSerVal-288 close to the active site. replaced by ProProLeuArgSer PPLRS clone 3. Slow self-reactivation after inhibition by paraoxon
Kinetic parameters|none


References:
    Title: Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity
    Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA, Jr., Rubtsova MP, Kartseva OV and Altman S <15 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 114:2550, 2017 : PubMed

            




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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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