Mutation

Kinetic parameters

Tree Display

AceDB Schema

XML Display

Feedback

Mutation Report for: T120E_human-BCHE

T120E_human-BCHE
Gene_Locus|human-BCHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|T120E
Torpedo number|122
Summary|
Comment|p.T120E Thr120Glu (p.T148E Thr148Glu in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic Site;no changes in Kcat Km for esters
Kinetic parameters|BW284C51_T120E_human-BCHE,
Butyrylthiocholine_T120E_human-BCHE,
Dibucaine_T120E_human-BCHE,
Solanine_T120E_human-BCHE,
Succinylcholine~Suxamethonium_T120E_human-BCHE,
Tacrine_T120E_human-BCHE


References:
    Title: Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis
    Loewenstein-Lichtenstein Y, Glick D, Gluzman N, Sternfeld M, Zakut H, Soreq H
    Ref: Molecular Pharmacology, 50:1423, 1996 : PubMed

            




Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer