Gene Locus : ratno-Ces1d
Mode of mutation : Site directed mutagenesis
Disease :
Summary : cholesteryl esterase activity Wallace_2001_J.Biol.Chem_276_33165
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : cholesteryl esterase activity
Torpedo_number : 399
Kinetic Parameter : No kinetic parameter
News : No news
Comment : Increases specific activity against PNPC by 8-fold, does not increase activity against PNPA, no activity on cholesteryl oleate. Increases activity on PNPC compared to activity on PNPA\; when associated with R-186\; T-491 and E-492. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold\; when associated with S-506. || p.Met423Ile
Title : Mutation of residues 423 (Met\/Ile), 444 (Thr\/Met), and 506 (Asn\/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase - Wallace_2001_J.Biol.Chem_276_33165 |
Author(s) : Wallace TJ , Kodsi EM , Langston TB , Gergis MR , Grogan WM |
Ref : Journal of Biological Chemistry , 276 :33165 , 2001 |
Abstract : Wallace_2001_J.Biol.Chem_276_33165 |
ESTHER : Wallace_2001_J.Biol.Chem_276_33165 |
PubMedSearch : Wallace_2001_J.Biol.Chem_276_33165 |
PubMedID: 11429416 |
Gene_locus related to this paper: ratno-Ces1d |