Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : OP-resistance Not as strong resistance as G117H Zhang_2012_J.Pharmacol.Exp.Ther_343_673
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 127
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.L125V Leu125Val (p.L153V Leu153Val in primary sequence with 28 amino-acids signal peptide) Not as strong resistance as G117H
| Title : Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen - Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| Author(s) : Zhang J , Chen S , Ralph EC , Dwyer MA , Cashman JR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :673 , 2012 |
| Abstract : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| ESTHER : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| PubMedSearch : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| PubMedID: 22956723 |