Gene Locus : mouse-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Electrostatic\;influence TFK inhibition but not ionic strength dependance\;Radic_1997_J.Biol.Chem_272_23265 || Aging\;decreased the affinity of soman for AChE, slowed the reactivation of soman-inhibited AChE by HI-6, and decreased the aging of mutant AChE\;Saxena_1997_Biochem.Pharmacol_54_269
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Electrostatic || Aging
Torpedo_number : 199
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Glu202Gln
| Title : Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin - Radic_1997_J.Biol.Chem_272_23265 |
| Author(s) : Radic Z , Kirchhoff PD , Quinn DM , McCammon JA , Taylor P |
| Ref : Journal of Biological Chemistry , 272 :23265 , 1997 |
| Abstract : Radic_1997_J.Biol.Chem_272_23265 |
| ESTHER : Radic_1997_J.Biol.Chem_272_23265 |
| PubMedSearch : Radic_1997_J.Biol.Chem_272_23265 |
| PubMedID: 9287336 |
| Title : Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning - Saxena_1997_Biochem.Pharmacol_54_269 |
| Author(s) : Saxena A , Maxwell DM , Quinn DM , Radic Z , Taylor P , Doctor BP |
| Ref : Biochemical Pharmacology , 54 :269 , 1997 |
| Abstract : Saxena_1997_Biochem.Pharmacol_54_269 |
| ESTHER : Saxena_1997_Biochem.Pharmacol_54_269 |
| PubMedSearch : Saxena_1997_Biochem.Pharmacol_54_269 |
| PubMedID: 9271331 |