Gene Locus : torca-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Acylation lower activity reduction in kcat but not Km substrate inhibition eliminated Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 Radic_1992_Biochemistry_31_9760 || Phosphorylation Decreased affinity for reversible inhibitors and reduced rates of phosphorylation carbamylation Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 Radic_1992_Biochemistry_31_9760
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acylation,Phosphorylation
Torpedo_number : 199
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.Glu199Asp
| Title : Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants - Radic_1992_Biochemistry_31_9760 |
| Author(s) : Radic Z , Gibney G , Kawamoto S , MacPhee-Quigley K , Bongiorno C , Taylor P |
| Ref : Biochemistry , 31 :9760 , 1992 |
| Abstract : Radic_1992_Biochemistry_31_9760 |
| ESTHER : Radic_1992_Biochemistry_31_9760 |
| PubMedSearch : Radic_1992_Biochemistry_31_9760 |
| PubMedID: 1356436 |
| Title : Mutagenesis of essential functional residues in acetylcholinesterase - Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 |
| Author(s) : Gibney G , Camp S , Dionne M , MacPhee-Quigley K , Taylor P |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 87 :7546 , 1990 |
| Abstract : Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 |
| ESTHER : Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 |
| PubMedSearch : Gibney_1990_Proc.Natl.Acad.Sci.U.S.A_87_7546 |
| PubMedID: 2217185 |