Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Succinylthiocholine binding Higher Km Masson_1997_Biochemistry_36_2266 || Aspirin hydrolysis Masson_1998_Biochim.Biophys.Acta_1387_41
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Succinylthiocholine binding
Torpedo_number : 72
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.D70K Asp70Lys (p.D98K Asp98Lys in primary sequence with 28 amino-acids signal peptide) Higher Km
| Title : Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters - Masson_1998_Biochim.Biophys.Acta_1387_41 |
| Author(s) : Masson P , Froment MT , Fortier PL , Visicchio JE , Bartels CF , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1387 :41 , 1998 |
| Abstract : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| ESTHER : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| PubMedSearch : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| PubMedID: 9748494 |
| Title : Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase - Masson_1997_Biochem.J_325_53 |
| Author(s) : Masson P , Froment MT , Bartels CF , Lockridge O |
| Ref : Biochemical Journal , 325 :53 , 1997 |
| Abstract : Masson_1997_Biochem.J_325_53 |
| ESTHER : Masson_1997_Biochem.J_325_53 |
| PubMedSearch : Masson_1997_Biochem.J_325_53 |
| PubMedID: 9224629 |
| Title : Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase - Masson_1997_Biochemistry_36_2266 |
| Author(s) : Masson P , Legrand P , Bartels CF , Froment MT , Schopfer LM , Lockridge O |
| Ref : Biochemistry , 36 :2266 , 1997 |
| Abstract : Masson_1997_Biochemistry_36_2266 |
| ESTHER : Masson_1997_Biochemistry_36_2266 |
| PubMedSearch : Masson_1997_Biochemistry_36_2266 |
| PubMedID: 9047329 |