Gene Locus : human-ACHE
Mode of mutation : Natural mutant
Disease :
Summary : Natural mutation ACHE:G\/C Asp134His snp Valle_2011_J.Pharmacol.Exp.Ther_338_125 || Oxime interaction no effect Cochran_2011_J.Biol.Chem_286_29718
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : snp || Natural mutation
Torpedo_number : 131
Kinetic Parameter : No kinetic parameter
News : APRIL-18-2011
Comment : p.D134H Asp134His (p.D165H Asp165His in primary sequence with 31 amino-acids signal peptide) (Valle et al. 2011)
| Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718 |
| Author(s) : Cochran R , Kalisiak J , Kucukkilinc TT , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :29718 , 2011 |
| Abstract : Cochran_2011_J.Biol.Chem_286_29718 |
| ESTHER : Cochran_2011_J.Biol.Chem_286_29718 |
| PubMedSearch : Cochran_2011_J.Biol.Chem_286_29718 |
| PubMedID: 21730071 |
| Title : Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits - Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| Author(s) : Valle AM , Radic Z , Rana BK , Mahboubi V , Wessel J , Shih PA , Rao F , O'Connor DT , Taylor P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :125 , 2011 |
| Abstract : Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| ESTHER : Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| PubMedSearch : Valle_2011_J.Pharmacol.Exp.Ther_338_125 |
| PubMedID: 21493754 |