Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Binding of inhibitors smaller dimension of the active-site gorge Saxena_1999_Chem.Biol.Interact_119-120_61 || Substrate activation substrate activation Masson_2001_Biochim.Biophys.Acta_1544_166 || Aricept~Donepezil~E2020 inhibition 10-fold increase Ki vs WT Saxena_2003_Eur.J.Biochem_270_4447 || Cationic triarylmethane dyes Biberoglu_2011_Arch.Biochem.Biophys_511_64
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity || Substrate activation || Aricept~Donepezil~E2020 inhibition || Cationic triarylmethane dyes
Torpedo_number : 330
Kinetic Parameter : No kinetic parameter
News : No news
Comment : p.A328F Ala328Phe (p.A356F Ala356Phe in primary sequence with 28 amino-acids signal peptide) Substrate activation\; Aricept~Donepezil~E2020 inhibition\;10-fold increase Ki vs WT
| Title : The role of Phe329 in binding of cationic triarylmethane dyes to human butyrylcholinesterase - Biberoglu_2011_Arch.Biochem.Biophys_511_64 |
| Author(s) : Biberoglu K , Tacal O , Akbulut H |
| Ref : Archives of Biochemistry & Biophysics , 511 :64 , 2011 |
| Abstract : Biberoglu_2011_Arch.Biochem.Biophys_511_64 |
| ESTHER : Biberoglu_2011_Arch.Biochem.Biophys_511_64 |
| PubMedSearch : Biberoglu_2011_Arch.Biochem.Biophys_511_64 |
| PubMedID: 21530486 |
| Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases - Saxena_2003_Eur.J.Biochem_270_4447 |
| Author(s) : Saxena A , Fedorko JM , Vinayaka CR , Medhekar R , Radic Z , Taylor P , Lockridge O , Doctor BP |
| Ref : European Journal of Biochemistry , 270 :4447 , 2003 |
| Abstract : Saxena_2003_Eur.J.Biochem_270_4447 |
| ESTHER : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedSearch : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedID: 14622273 |
| Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166 |
| Author(s) : Masson P , Xie W , Froment MT , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001 |
| Abstract : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| ESTHER : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedID: 11341926 |
| Gene_locus related to this paper: human-BCHE |
| Title : Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase - Saxena_1999_Chem.Biol.Interact_119-120_61 |
| Author(s) : Saxena A , Redman AM , Jiang X , Lockridge O , Doctor BP |
| Ref : Chemico-Biological Interactions , 119-120 :61 , 1999 |
| Abstract : Saxena_1999_Chem.Biol.Interact_119-120_61 |
| ESTHER : Saxena_1999_Chem.Biol.Interact_119-120_61 |
| PubMedSearch : Saxena_1999_Chem.Biol.Interact_119-120_61 |
| PubMedID: 10421439 |