sEH-LTA4H-14
Multitarget anti-inflammatory drug Compound 14: dual inhibitor of soluble epoxide hydrolase (sEH) and LTA4 hydrolase (Leukotriene A-4 hydrolase LTA4H) with sub-micromolar activity towards both targets IC50 sEH 0.3 +/- 0.1 muM IC50 LTA4H 0.2 +/- 0.1 muM
General
Type : Urea derivative,LTA4-hydrolase-inhibitor,Multitarget,Sulfur Compound
Chemical_Nomenclature : 2-(4-(benzo[d]thiazol-2-yloxy)-2-fluorophenyl)-N-(4-fluorophenethyl)acetamide
Canonical SMILES : C1=CC=CC2=C1N=C(S2)OC3=CC(=C(C=C3)CC(=O)N(CCC4=CC=C(C=C4)F)[H])F
InChI : InChI=1S\/C23H18F2N2O2S\/c24-17-8-5-15(6-9-17)11-12-26-22(28)13-16-7-10-18(14-19(16)25)29-23-27-20-3-1-2-4-21(20)30-23\/h1-10,14H,11-13H2,(H,26,28)
InChIKey : PQOJWVHLJYMILK-UHFFFAOYSA-N
Other name(s) :
MW : 424.11
Formula : C23H18F2N2O2S
CAS_number :
PubChem :
UniChem : PQOJWVHLJYMILK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : sEH-LTA4H-14 ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX2
References (1)
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| ESTHER : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |