p-Iodo-Phe-Pyr-CN
General
Type : Peptide,Pyrrolidine,Cyanide
Chemical_Nomenclature : 1-(2-(S)-cyanopyrrolidin-1-yl)-3-(4-iodophenyl)-1-oxopropan-2-aminium
Canonical SMILES : C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)I)N)C#N
InChI : InChI=1S\/C14H16IN3O\/c15-11-5-3-10(4-6-11)8-13(17)14(19)18-7-1-2-12(18)9-16\/h3-6,12-13H,1-2,7-8,17H2\/t12-,13-\/m0\/s1
InChIKey : PQFUJTFHVDWNOF-STQMWFEESA-N
Other name(s) : CHEMBL199881,D0PB2M,SCHEMBL3260399,BDBM11116,4-iodophenyl-alaninyl-(S)-2-cyano-pyrrolidine,4-substituted phenylalanine cyano-(S)-pyrrolidine deriv. 3
MW : 369.20
Formula : C14H16IN3O
CAS_number :
PubChem : 23645372
UniChem : PQFUJTFHVDWNOF-STQMWFEESA-N
IUPHAR :
Wikipedia :
Target
Families : p-Iodo-Phe-Pyr-CN ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 1ORW Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor
Protein : pig-dpp4
References (2)
| Title : Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors - Qiao_2006_Bioorg.Med.Chem.Lett_16_123 |
| Author(s) : Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP , Bayoumy SS , Williams R , Deckman IC , Dasgupta M , Reed RL , Huebert ND , Tomczuk BE , Moriarty KJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :123 , 2006 |
| Abstract : Qiao_2006_Bioorg.Med.Chem.Lett_16_123 |
| ESTHER : Qiao_2006_Bioorg.Med.Chem.Lett_16_123 |
| PubMedSearch : Qiao_2006_Bioorg.Med.Chem.Lett_16_123 |
| PubMedID: 16236500 |
| Gene_locus related to this paper: human-DPP4 |
| Title : The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism - Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
| Author(s) : Engel M , Hoffmann T , Wagner L , Wermann M , Heiser U , Kiefersauer R , Huber R , Bode W , Demuth HU , Brandstetter H |
| Ref : Proc Natl Acad Sci U S A , 100 :5063 , 2003 |
| Abstract : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
| ESTHER : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
| PubMedSearch : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
| PubMedID: 12690074 |
| Gene_locus related to this paper: pig-dpp4 |