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Inhibitor Report for: mitoFP

mitoFP localize to the mitochondria via an appended triphenylphosphonium group, which delivers the probe to the mitochondria based on the electrochemical potential.


General
Type Organophosphate
Chemical_Nomenclature 4-[fluoro(octoxy)phosphoryl]butyl-triphenylphosphanium;fluoride
Canonical SMILES CCCCCCCCOP(=O)(CCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)F.[F-]
InChI InChI=1S/C30H40FO2P2.FH/c1-2-3-4-5-6-16-25-33-35(31,32)27-18-17-26-34(28-19-10-7-11-20-28,29-21-12-8-13-22-29)30-23-14-9-15-24-30;/h7-15,19-24H,2-6,16-18,25-27H2,1H3;1H/q+1;/p-1
InChIKey OMZNGJMDMWCXQP-UHFFFAOYSA-M
Other name(s)
________________________________________________________________________________________________
MW|532.6
Formula|C30H40F2O2P2
CAS_number|
PubChem|139033750
UniChem|OMZNGJMDMWCXQP-UHFFFAOYSA-M
IUPHAR|
Wikipedia|

Target
Families | mitoFP ligand of proteins in family: ABHD10, LYsophospholipase_carboxylesterase
Protein | mouse-abhda, human-ABHD10, human-LYPLA1

References:
Search PubMed for references concerning: mitoFP
    Title: ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5
    Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC
    Ref: Nat Chemical Biology, 15:1232, 2019 : PubMed