Fehr, L., Carvalho, L.A.R., Ross, B.H., Lum, K., Vieira, A.C., Kiefersauer, R., Geiss-Friedlander, R., Kaiser, M., Rodrigues, T., Lucas, S.D., Cravatt, B.F., Huber, R., Moreira, R. || In the structure the beta-lactam ring is described as open
Type : Piperazine,beta-Lactam
Chemical_Nomenclature :
Canonical SMILES : C1=CC(=CC=C1Br)CN2CCN(CC2)CC3=CC(=CC=C3)N4C(C(C4=O)(CC)CC)=O
InChI : InChI=1S\/C25H30BrN3O2\/c1-3-25(4-2)23(30)29(24(25)31)22-7-5-6-20(16-22)18-28-14-12-27(13-15-28)17-19-8-10-21(26)11-9-19\/h5-11,16H,3-4,12-15,17-18H2,1-2H3
InChIKey : BGOMDQXQHRMQKC-UHFFFAOYSA-N
Other name(s) :
MW : 484.43
Formula : C25H30BrN3O2
CAS_number :
PubChem :
UniChem : BGOMDQXQHRMQKC-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : beta-lactam-L84-closed ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 7OZ7 Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, L84
Protein : human-DPP8
Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
Ref : Angew Chem Int Ed Engl , : , 2022 |
Abstract : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
ESTHER : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
PubMedID: 36089535 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |