Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: VX-Biotin

Serine Hydrolase probe consisting of a tag linked to a VX group, whichcovalently labels serine of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe). Useful as ABPP probe but not specific: Labels lots of non serine hydrolases


General
Type Organophosphate, ABPP-Probe, Imidazole, Sulfur Compound, Biotin derivative, Derivative of VX
Chemical_Nomenclature
Canonical SMILES [P](C)(SCC[N+](C(C)C)C(C)C)(=O)OCCCCCCCCCCCNC(CCCCC1C2C(CS1)NC(N2)=O)=O
InChI InChI=1S/C30H59N4O4PS2/c1-24(2)34(25(3)4)20-22-41-39(5,37)38-21-16-12-10-8-6-7-9-11-15-19-31-28(35)18-14-13-17-27-29-26(23-40-27)32-30(36)33-29/h24-27,29H,6-23H2,1-5H3,(H,31,35)(H2,32,33,36)/p+1
InChIKey IFUSBFMUVYCLLZ-UHFFFAOYSA-O
Other name(s)
________________________________________________________________________________________________
MW|635.93
Formula|C30H60N4O4PS2+
CAS_number|
PubChem|
UniChem|IFUSBFMUVYCLLZ-UHFFFAOYSA-O
IUPHAR|
Wikipedia|


References:
Search PubMed for references concerning: VX-Biotin
    Title: Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A
    Bouknight KD, Jurkouich KM, Compton JR, Khavrutskii IV, Guelta MA, Harvey SP, Legler PM
    Ref: Biochemical Pharmacology, :113980, 2020 : PubMed

            

    Title: Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX
    Carmany D, Walz AJ, Hsu FL, Benton B, Burnett D, Gibbons J, Noort D, Glaros T, Sekowski JW
    Ref: Chemical Research in Toxicology, 30:1076, 2017 : PubMed