Trichloropropene-oxide
A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
General
Type : Epoxide
Chemical_Nomenclature : 2-(trichloromethyl)oxirane
Canonical SMILES : C1C(O1)C(Cl)(Cl)Cl
InChI : InChI=1S\/C3H3Cl3O\/c4-3(5,6)2-1-7-2\/h2H,1H2
InChIKey : VFEXYZINKMLLAK-UHFFFAOYSA-N
Other name(s) : 2-(Trichloromethyl)oxirane,Trichloropropene oxide,TCPO,SCHEMBL2550267,1,2-Epoxy-3,3,3-trichloropropane,(Trichloromethyl)oxirane
MW : 161.41
Formula : C3H3Cl3O
CAS_number : 3083-23-6
PubChem : 18321
UniChem : VFEXYZINKMLLAK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Trichloropropene-oxide ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX1
References (12)
| Title : Oviductal microsomal epoxide hydrolase (EPHX1) reduces reactive oxygen species (ROS) level and enhances preimplantation mouse embryo development - Cheong_2009_Biol.Reprod_81_126 |
| Author(s) : Cheong AW , Lee YL , Liu WM , Yeung WS , Lee KF |
| Ref : Biol Reprod , 81 :126 , 2009 |
| Abstract : Cheong_2009_Biol.Reprod_81_126 |
| ESTHER : Cheong_2009_Biol.Reprod_81_126 |
| PubMedSearch : Cheong_2009_Biol.Reprod_81_126 |
| PubMedID: 19321813 |
| Title : Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL\/6J mice - Hartsfield_1995_Biochem.Mol.Med_56_131 |
| Author(s) : Hartsfield JK, Jr. , Holmes LB , Morel JG |
| Ref : Biochemical & Molecular Medicine , 56 :131 , 1995 |
| Abstract : Hartsfield_1995_Biochem.Mol.Med_56_131 |
| ESTHER : Hartsfield_1995_Biochem.Mol.Med_56_131 |
| PubMedSearch : Hartsfield_1995_Biochem.Mol.Med_56_131 |
| PubMedID: 8825076 |
| Title : An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes - Tingle_1993_Biochem.Pharmacol_46_1529 |
| Author(s) : Tingle MD , Pirmohamed M , Templeton E , Wilson AS , Madden S , Kitteringham NR , Park BK |
| Ref : Biochemical Pharmacology , 46 :1529 , 1993 |
| Abstract : Tingle_1993_Biochem.Pharmacol_46_1529 |
| ESTHER : Tingle_1993_Biochem.Pharmacol_46_1529 |
| PubMedSearch : Tingle_1993_Biochem.Pharmacol_46_1529 |
| PubMedID: 8240407 |
| Title : Human liver cytosolic epoxide hydrolases - Schladt_1988_Eur.J.Biochem_176_715 |
| Author(s) : Schladt L , Thomas H , Hartmann R , Oesch F |
| Ref : European Journal of Biochemistry , 176 :715 , 1988 |
| Abstract : Schladt_1988_Eur.J.Biochem_176_715 |
| ESTHER : Schladt_1988_Eur.J.Biochem_176_715 |
| PubMedSearch : Schladt_1988_Eur.J.Biochem_176_715 |
| PubMedID: 3169021 |
| Title : Purification of microsomal epoxide hydrolase from liver of rhesus monkey: partial separation of cis- and trans-stilbene oxide hydrolase - Moody_1987_Arch.Biochem.Biophys_258_156 |
| Author(s) : Moody DE , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 258 :156 , 1987 |
| Abstract : Moody_1987_Arch.Biochem.Biophys_258_156 |
| ESTHER : Moody_1987_Arch.Biochem.Biophys_258_156 |
| PubMedSearch : Moody_1987_Arch.Biochem.Biophys_258_156 |
| PubMedID: 3310896 |
| Title : Selective inhibition and selective induction of multiple microsomal epoxide hydrolases - Guenthner_1986_Biochem.Pharmacol_35_839 |
| Author(s) : Guenthner TM |
| Ref : Biochemical Pharmacology , 35 :839 , 1986 |
| Abstract : Guenthner_1986_Biochem.Pharmacol_35_839 |
| ESTHER : Guenthner_1986_Biochem.Pharmacol_35_839 |
| PubMedSearch : Guenthner_1986_Biochem.Pharmacol_35_839 |
| PubMedID: 3954789 |
| Title : Nuclear metabolism. II. Further studies on epoxide hydrolase activity - Gazzotti_1981_Chem.Biol.Interact_35_311 |
| Author(s) : Gazzotti G , Garattini E , Salmona M |
| Ref : Chemico-Biological Interactions , 35 :311 , 1981 |
| Abstract : Gazzotti_1981_Chem.Biol.Interact_35_311 |
| ESTHER : Gazzotti_1981_Chem.Biol.Interact_35_311 |
| PubMedSearch : Gazzotti_1981_Chem.Biol.Interact_35_311 |
| PubMedID: 7226277 |
| Title : Effects of the epoxide hydrase inhibitor, 1,1,1-trichloropropane-2,3-oxide on the genetic activity of aflatoxin B1 metabolites in in vitro activation test systems - Callen_1978_Mutat.Res_49_371 |
| Author(s) : Callen DF , Ong TM |
| Ref : Mutat Res , 49 :371 , 1978 |
| Abstract : Callen_1978_Mutat.Res_49_371 |
| ESTHER : Callen_1978_Mutat.Res_49_371 |
| PubMedSearch : Callen_1978_Mutat.Res_49_371 |
| PubMedID: 147417 |
| Title : Benzo(a)pyrene metabolism in mouse epidermis. Analysis by high pressure liquid chromatography and DNA binding - Berry_1977_Chem.Biol.Interact_18_129 |
| Author(s) : Berry DL , Bracken WR , Slaga TJ , Wilson NM , Butty SG , Juchau MR |
| Ref : Chemico-Biological Interactions , 18 :129 , 1977 |
| Abstract : Berry_1977_Chem.Biol.Interact_18_129 |
| ESTHER : Berry_1977_Chem.Biol.Interact_18_129 |
| PubMedSearch : Berry_1977_Chem.Biol.Interact_18_129 |
| PubMedID: 890843 |
| Title : Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue - Martz_1977_J.Pharmacol.Exp.Ther_203_231 |
| Author(s) : Martz F , Failinger C, 3rd , Blake DA |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 203 :231 , 1977 |
| Abstract : Martz_1977_J.Pharmacol.Exp.Ther_203_231 |
| ESTHER : Martz_1977_J.Pharmacol.Exp.Ther_203_231 |
| PubMedSearch : Martz_1977_J.Pharmacol.Exp.Ther_203_231 |
| PubMedID: 909055 |
| Title : Characterization of rat lung epoxide (styrene oxide) hydrase with a modified radioactive assay of improved sensitivity - Seidegard_1977_Cancer.Res_37_1075 |
| Author(s) : Seidegard J , DePierre JW , Moron MS , Johannesen KA , Ernster L |
| Ref : Cancer Research , 37 :1075 , 1977 |
| Abstract : Seidegard_1977_Cancer.Res_37_1075 |
| ESTHER : Seidegard_1977_Cancer.Res_37_1075 |
| PubMedSearch : Seidegard_1977_Cancer.Res_37_1075 |
| PubMedID: 402999 |