Tat-(1-9)

DPPIV peptidase activity is inhibited by N-terminal nonapeptide Tat-(1-9) of Tat protein from human immunodeficiency virus (HIV)-1 with amino acid sequence MDPVDPNIE

General

Type : Peptide,Pyrrolidine,Sulfur Compound

Chemical_Nomenclature : (2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]pentanedioic acid

Canonical SMILES : CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(CCSC)N

InChI : InChI=1S\/C43H68N10O17S\/c1-6-21(4)34(40(66)46-23(43(69)70)11-12-30(55)56)51-36(62)24(17-29(45)54)47-37(63)27-9-7-14-52(27)42(68)26(19-32(59)60)49-39(65)33(20(2)3)50-38(64)28-10-8-15-53(28)41(67)25(18-31(57)58)48-35(61)22(44)13-16-71-5\/h20-28,33-34H,6-19,44H2,1-5H3,(H2,45,54)(H,46,66)(H,47,63)(H,48,61)(H,49,65)(H,50,64)(H,51,62)(H,55,56)(H,57,58)(H,59,60)(H,69,70)\/t21-,22-,23-,24-,25-,26-,27-,28-,33-,34-\/m0\/s1

InChIKey : FBRBBGLUJRXRGJ-MQMIXWJCSA-N

Other name(s) : HIV-1 Tat(1-9),HIV-1 tat Protein (1-9),200203-20-9,H-Met-Asp-Pro-Val-Asp-Pro-Asn-Ile-Glu-OH,MDPVDPNIE


MW : 1029.13

Formula : C43H68N10O17S

CAS_number :

PubChem : 100915314

UniChem : FBRBBGLUJRXRGJ-MQMIXWJCSA-N

IUPHAR :

Wikipedia :

Target

Families : Tat-(1-9) ligand of proteins in family: DPP4N_Peptidase_S9

Stucture : 2BGR HIV-1 Tat Derived Nonapeptides Tat(1-9) Bound To The Active Site Of Dipeptidyl Peptidase IV (Cd26)

Protein : human-DPP4

References (1)

Title : Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26) - Weihofen_2005_J.Biol.Chem_280_14911
Author(s) : Weihofen WA , Liu J , Reutter W , Saenger W , Fan H
Ref : Journal of Biological Chemistry , 280 :14911 , 2005
Abstract : Weihofen_2005_J.Biol.Chem_280_14911
ESTHER : Weihofen_2005_J.Biol.Chem_280_14911
PubMedSearch : Weihofen_2005_J.Biol.Chem_280_14911
PubMedID: 15695814
Gene_locus related to this paper: human-DPP4