Tacrine-selegiline-7d
hAChE: IC50 = 1.57 microM, hBuChE: IC50 = 0.43 microM) and MAOs (hMAO-A: IC50 = 2.30 microM, hMAO-B: IC50 = 4.75 microM)
General
Type : Multitarget,Monoamine-oxidase-inhibitor,Acridine,Derivative of Tacrine,Alkyl linked bis-ligand
Chemical_Nomenclature : N-methyl-N-(4-(((6-(methyl(prop-2-yn-1-yl)amino)hexyl)oxy)methyl)benzyl)-1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCCC3)N(C)CC4=CC=C(C=C4)COCCCCCCN(C)CC#C
InChI : InChI=1S\/C32H41N3O\/c1-4-21-34(2)22-11-5-6-12-23-36-25-27-19-17-26(18-20-27)24-35(3)32-28-13-7-9-15-30(28)33-31-16-10-8-14-29(31)32\/h1,7,9,13,15,17-20H,5-6,8,10-12,14,16,21-25H2,2-3H3
InChIKey : QBYHXBDROOPIFK-UHFFFAOYSA-N
Other name(s) : Compound 7d
MW : 484.33
Formula : C32H42N3O
CAS_number :
PubChem :
UniChem : QBYHXBDROOPIFK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Tacrine-selegiline-7d ligand of proteins in family: BCHE || ACHE
Stucture :
Protein : human-BCHE || human-ACHE
References (1)
| Title : In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer's Disease - Huang_2024_Drug.Des.Devel.Ther_18_133 |
| Author(s) : Huang ST , Luo JC , Zhong GH , Teng LP , Yang CY , Tang CL , Jing L , Zhou ZB , Liu J , Jiang N |
| Ref : Drug Des Devel Ther , 18 :133 , 2024 |
| Abstract : Huang_2024_Drug.Des.Devel.Ther_18_133 |
| ESTHER : Huang_2024_Drug.Des.Devel.Ther_18_133 |
| PubMedSearch : Huang_2024_Drug.Des.Devel.Ther_18_133 |
| PubMedID: 38283137 |