Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Tacrine-pentylmethylene-tolylsulfonamide

IC50 microM AChE 0.131 +/- 0.01 BChE 0.0680 +/- 0.0014


General
Type Alkyl linked bis-ligand, Derivative of Tacrine, Sulfur Compound, Sulfonamide, Benzenesulfonamide
Chemical_Nomenclature 4-Methyl-N-(5-(1,2,3,4-tetrahydro-acridin-9-ylamino)-pentyl)-benzenesulfonamide
Canonical SMILES N(CCCCCN[S](=O)(=O)C1=CC=C(C=C1)C)C2=C4C(=NC3=CC=CC=C23)CCCC4
InChI InChI=1S/C25H31N3O2S/c1-19-13-15-20(16-14-19)31(29,30)27-18-8-2-7-17-26-25-21-9-3-5-11-23(21)28-24-12-6-4-10-22(24)25/h3,5,9,11,13-16,27H,2,4,6-8,10,12,17-18H2,1H3,(H,26,28)
InChIKey AZQJBDNDDDGKPV-UHFFFAOYSA-N
Other name(s) Compound 7h
________________________________________________________________________________________________
MW|437.59
Formula|C25H31N3O2S
CAS_number|
PubChem|
UniChem|AZQJBDNDDDGKPV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Tacrine-pentylmethylene-tolylsulfonamide ligand of proteins in family: ACHE, BCHE
Protein | human-ACHE, human-BCHE

References:
Search PubMed for references concerning: Tacrine-pentylmethylene-tolylsulfonamide
    Title: New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment
    Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Astakhova TY, Rudakova EV, Proshin AN, Serkov IV, Radchenko EV and Richardson RJ <2 more author(s)>
    Ref: Molecules, 25:3915, 2020 : PubMed