Tacrine-Sibiriline-Cpd7
IC50 AChE 30.35 +/- 2.07 nM; BChE 48.03 +/- 6.41; potent antioxidant and anti-inflammatory
General
Type : Multitarget,Acridine,Derivative of Tacrine,Alkyl linked bis-ligand,Pyridine,Carbamate,Pyrrolidine
Chemical_Nomenclature : 4-(1H-pyrrolo [2,3-b]pyridin-2-yl)phenyl (6-((6-fluoro-1,2,3,4-tetrahydroacridin-9-yl)amino)hexyl)carbamate
Canonical SMILES : C16=C(C(=C2C(=N1)C=C(C=C2)F)NCCCCCCNC(=O)OC3=CC=C(C=C3)C4=CC5=C([N]4)N=CC=C5)CCCC6
InChI : InChI=1S\/C33H34FN5O2\/c34-24-13-16-27-30(21-24)38-28-10-4-3-9-26(28)31(27)35-17-5-1-2-6-18-37-33(40)41-25-14-11-22(12-15-25)29-20-23-8-7-19-36-32(23)39-29\/h7-8,11-16,19-21H,1-6,9-10,17-18H2,(H,35,38)(H,36,39)(H,37,40)
InChIKey : ZMLLZOVFQZLICZ-UHFFFAOYSA-N
Other name(s) : Compound C7
MW : 551.66
Formula : C33H34FN5O2
CAS_number :
PubChem :
UniChem : ZMLLZOVFQZLICZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Tacrine-Sibiriline-Cpd7 ligand of proteins in family: BCHE || ACHE
Stucture :
Protein : human-BCHE || human-ACHE
References (1)
| Title : Corrigendum to Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease [Eur. J. Med. Chem. 265 (2024) 116071] - |
| Author(s) : Liu Y , Ma C , Li Y , Li M , Cui T , Zhao X , Li Z , Jia H , Wang H , Xiu X , Hu D , Zhang R , Wang N , Liu P , Yang H , Cheng M |
| Ref : Eur Journal of Medicinal Chemistry , :116169 , 2024 |
| PubMedID: 38290915 |