Tacrine
Tacrine is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine therapy is associated with a very high rate of serum aminotransferase elevations during therapy and has been linked to several instances of clinically apparent, acute liver injury. || C13H14N2 * HCl MW 234.71 CAS 1684-40-8 || Treatment of Alzheimer Disease, trademark is cognex. Reversible inhibitor of both AChE and BChE Tacrine is an oral acetylcholinesterase inhibitor previously used for therapy of Alzheimer disease. Tacrine therapy is associated with a very high rate of serum aminotransferase elevations during therapy and has been linked to several instances of clinically apparent, acute liver injury. release of endogenous 5-hydroxytryptamine (5-HT) not through a cholinergic, reserpine- or amphetamine-like mechanism or through inhibition of reuptake. The release may occur via blockade of 4-AP-insensitive K+ channels
General
Type : Derivative of Tacrine,Acridine
Chemical_Nomenclature : 1,2,3,4-tetrahydroacridin-9-amine
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)N
InChI : InChI=1S\/C13H14N2\/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13\/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
InChIKey : YLJREFDVOIBQDA-UHFFFAOYSA-N
Other name(s) : 1,2,3,4,-tetrahydro-9 aminoacridine,Tetrahydroaminacrine,Tetrahydroaminoacridine,Cognex,tetrahydroamino-acridine,THA
MW : 198.27
Formula : C13H14N2
CAS_number : 321-64-2
PubChem : 1935
UniChem : YLJREFDVOIBQDA-UHFFFAOYSA-N
IUPHAR : 6687
Wikipedia :
Target
Families : Tacrine ligand of proteins in family: ACHE
Stucture :
Protein : torca-ACHE || human-BCHE || human-CES1 || human-ACHE
References (71)
| Title : Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery - Dileep_2022_Int.J.Biol.Macromol_210_172 |
| Author(s) : Dileep KV , Ihara K , Mishima-Tsumagari C , Kukimoto-Niino M , Yonemochi M , Hanada K , Shirouzu M , Zhang KYJ |
| Ref : Int J Biol Macromol , 210 :172 , 2022 |
| Abstract : Dileep_2022_Int.J.Biol.Macromol_210_172 |
| ESTHER : Dileep_2022_Int.J.Biol.Macromol_210_172 |
| PubMedSearch : Dileep_2022_Int.J.Biol.Macromol_210_172 |
| PubMedID: 35526766 |
| Gene_locus related to this paper: human-ACHE |
| Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226 |
| Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM |
| Ref : Chemico-Biological Interactions , 203 :226 , 2013 |
| Abstract : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| ESTHER : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226 |
| PubMedID: 23123248 |
| Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341 |
| Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR |
| Ref : Chemical Biology , 10 :341 , 2003 |
| Abstract : Bencharit_2003_Chem.Biol_10_341 |
| ESTHER : Bencharit_2003_Chem.Biol_10_341 |
| PubMedSearch : Bencharit_2003_Chem.Biol_10_341 |
| PubMedID: 12725862 |
| Gene_locus related to this paper: human-CES1 |
| Title : Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity - Alhomida_2000_Toxicology_147_33 |
| Author(s) : Alhomida AS , Al-Rajhi AA , Kamal MA , Al-Jafari AA |
| Ref : Toxicology , 147 :33 , 2000 |
| Abstract : Alhomida_2000_Toxicology_147_33 |
| ESTHER : Alhomida_2000_Toxicology_147_33 |
| PubMedSearch : Alhomida_2000_Toxicology_147_33 |
| PubMedID: 10837930 |
| Title : Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease - Camps_2000_Mol.Pharmacol_57_409 |
| Author(s) : Camps P , Cusack B , Mallender WD , Achab RE , Morral J , Munoz-Torrero D , Rosenberry TL |
| Ref : Molecular Pharmacology , 57 :409 , 2000 |
| Abstract : Camps_2000_Mol.Pharmacol_57_409 |
| ESTHER : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedSearch : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedID: 10648652 |
| Title : Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys - Callahan_1999_Psychopharmacology.(Berl)_144_234 |
| Author(s) : Callahan MJ |
| Ref : Psychopharmacology (Berl) , 144 :234 , 1999 |
| Abstract : Callahan_1999_Psychopharmacology.(Berl)_144_234 |
| ESTHER : Callahan_1999_Psychopharmacology.(Berl)_144_234 |
| PubMedSearch : Callahan_1999_Psychopharmacology.(Berl)_144_234 |
| PubMedID: 10435389 |
| Title : In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects - Traykov_1999_Eur.J.Neurol_6_273 |
| Author(s) : Traykov L , Tavitian B , Jobert A , Boller F , Forette F , Crouzel C , Di Giamberardino L , Pappata S |
| Ref : Eur Journal of Neurology , 6 :273 , 1999 |
| Abstract : Traykov_1999_Eur.J.Neurol_6_273 |
| ESTHER : Traykov_1999_Eur.J.Neurol_6_273 |
| PubMedSearch : Traykov_1999_Eur.J.Neurol_6_273 |
| PubMedID: 10210906 |
| Title : Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents - Zhao_1999_Bioorg.Med.Chem_7_1637 |
| Author(s) : Zhao S , Totleben MJ , Freeman JP , Bacon CL , Fox GB , O'Driscoll E , Foley AG , Kelly J , Farrell U , Regan C , Mizsak SA , Szmuszkovicz J |
| Ref : Bioorganic & Medicinal Chemistry , 7 :1637 , 1999 |
| Abstract : Zhao_1999_Bioorg.Med.Chem_7_1637 |
| ESTHER : Zhao_1999_Bioorg.Med.Chem_7_1637 |
| PubMedSearch : Zhao_1999_Bioorg.Med.Chem_7_1637 |
| PubMedID: 10482456 |
| Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427 |
| Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998 |
| Abstract : Badia_1998_Bioorg.Med.Chem_6_427 |
| ESTHER : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedID: 9597187 |
| Title : Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications - Giacobini_1998_Neurochem.Int_32_413 |
| Author(s) : Giacobini E |
| Ref : Neurochem Int , 32 :413 , 1998 |
| Abstract : Giacobini_1998_Neurochem.Int_32_413 |
| ESTHER : Giacobini_1998_Neurochem.Int_32_413 |
| PubMedSearch : Giacobini_1998_Neurochem.Int_32_413 |
| PubMedID: 9676739 |
| Title : Safety of tacrine: clinical trials, treatment IND, and postmarketing experience - Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93 |
| Author(s) : Gracon SI , Knapp MJ , Berghoff WG , Pierce M , DeJong R , Lobbestael SJ , Symons J , Dombey SL , Luscombe FA , Kraemer D |
| Ref : Alzheimer Disease & Associated Disorders , 12 :93 , 1998 |
| Abstract : Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93 |
| ESTHER : Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93 |
| PubMedSearch : Gracon_1998_Alzheimer.Dis.Assoc.Disord_12_93 |
| PubMedID: 9651138 |
| Title : Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease - Riekkinen_1998_Neurosci_83_471 |
| Author(s) : Riekkinen M , Soininen H , Riekkinen P, Sr. , Kuikka J , Laakso M , Helkala EL , Partanen J , Riekkinen P, Jr. |
| Ref : Neuroscience , 83 :471 , 1998 |
| Abstract : Riekkinen_1998_Neurosci_83_471 |
| ESTHER : Riekkinen_1998_Neurosci_83_471 |
| PubMedSearch : Riekkinen_1998_Neurosci_83_471 |
| PubMedID: 9460755 |
| Title : Penetration of tacrine into cerebrospinal fluid in patients with Alzheimer's disease - Grothe_1998_J.Clin.Psychopharmacol_18_78 |
| Author(s) : Grothe DR , Piscitelli SC , Dukoff R , Fullerton T , Sunderland T , Molchan SE |
| Ref : J Clin Psychopharmacol , 18 :78 , 1998 |
| Abstract : Grothe_1998_J.Clin.Psychopharmacol_18_78 |
| ESTHER : Grothe_1998_J.Clin.Psychopharmacol_18_78 |
| PubMedSearch : Grothe_1998_J.Clin.Psychopharmacol_18_78 |
| PubMedID: 9472847 |
| Title : Functional and subcellular organelle changes in isolated rat and human hepatocytes induced by tetrahydroaminoacridine - Monteith_1998_Arch.Toxicol_72_147 |
| Author(s) : Monteith DK , Theiss JC , Haskins JR , de la Iglesia FA |
| Ref : Archives of Toxicology , 72 :147 , 1998 |
| Abstract : Monteith_1998_Arch.Toxicol_72_147 |
| ESTHER : Monteith_1998_Arch.Toxicol_72_147 |
| PubMedSearch : Monteith_1998_Arch.Toxicol_72_147 |
| PubMedID: 9520138 |
| Title : Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats - Meyer_1998_Brain.Res_786_252 |
| Author(s) : Meyer EM , King MA , Meyers C |
| Ref : Brain Research , 786 :252 , 1998 |
| Abstract : Meyer_1998_Brain.Res_786_252 |
| ESTHER : Meyer_1998_Brain.Res_786_252 |
| PubMedSearch : Meyer_1998_Brain.Res_786_252 |
| PubMedID: 9555043 |
| Title : Sensitivity of bovine retinal acetylcholinesterase (E.C. 3.1.1.7) toward tacrine: kinetic characterization - al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245 |
| Author(s) : Al-Jafari AA , Kamal MA , Alhomida AS |
| Ref : J Biochem Mol Toxicol , 12 :245 , 1998 |
| Abstract : al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245 |
| ESTHER : al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245 |
| PubMedSearch : al-Jafari_1998_J.Biochem.Mol.Toxicol_12_245 |
| PubMedID: 9580877 |
| Title : Responses induced by tacrine in neuronal and non-neuronal cell lines - De Ferrari_1998_J.Neurosci.Res_52_435 |
| Author(s) : De Ferrari GV , Von Bernhardi R , Calderon FH , Luza SC , Inestrosa NC |
| Ref : Journal of Neuroscience Research , 52 :435 , 1998 |
| Abstract : De Ferrari_1998_J.Neurosci.Res_52_435 |
| ESTHER : De Ferrari_1998_J.Neurosci.Res_52_435 |
| PubMedSearch : De Ferrari_1998_J.Neurosci.Res_52_435 |
| PubMedID: 9589388 |
| Title : Shuttle-box avoidance learning in mice: improvement by combined glucose and tacrine - Pavone_1998_Neurobiol.Learn.Mem_69_204 |
| Author(s) : Pavone F , Capone F , Battaglia M , Sansone M |
| Ref : Neurobiol Learn Mem , 69 :204 , 1998 |
| Abstract : Pavone_1998_Neurobiol.Learn.Mem_69_204 |
| ESTHER : Pavone_1998_Neurobiol.Learn.Mem_69_204 |
| PubMedSearch : Pavone_1998_Neurobiol.Learn.Mem_69_204 |
| PubMedID: 9619996 |
| Title : Tetrahydroaminoacridine, a cholinesterase inhibitor, and D-cycloserine, a partial NMDA receptor-associated glycine site agonist, enhances acquisition of spatial navigation - Riekkinen_1998_Neuroreport_9_1633 |
| Author(s) : Riekkinen P, Jr. , Ikonen S , Riekkinen M |
| Ref : Neuroreport , 9 :1633 , 1998 |
| Abstract : Riekkinen_1998_Neuroreport_9_1633 |
| ESTHER : Riekkinen_1998_Neuroreport_9_1633 |
| PubMedSearch : Riekkinen_1998_Neuroreport_9_1633 |
| PubMedID: 9631478 |
| Title : Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release - Allal_1998_Eur.J.Pharmacol_348_191 |
| Author(s) : Allal C , Lazartigues E , Tran MA , Brefel-Courbon C , Gharib C , Montastruc JL , Rascol O |
| Ref : European Journal of Pharmacology , 348 :191 , 1998 |
| Abstract : Allal_1998_Eur.J.Pharmacol_348_191 |
| ESTHER : Allal_1998_Eur.J.Pharmacol_348_191 |
| PubMedSearch : Allal_1998_Eur.J.Pharmacol_348_191 |
| PubMedID: 9652334 |
| Title : Effects of AF102B and tacrine on delayed match-to-sample in monkeys - O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665 |
| Author(s) : O'Neill J , Fitten LJ , Siembieda D , Halgren E , Kim E , Fisher A , Perryman K |
| Ref : Prog Neuropsychopharmacol Biological Psychiatry , 22 :665 , 1998 |
| Abstract : O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665 |
| ESTHER : O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665 |
| PubMedSearch : O'Neill_1998_Prog.Neuropsychopharmacol.Biol.Psychiatry_22_665 |
| PubMedID: 9682279 |
| Title : Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities - Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| Author(s) : Cheng DH , Tang XC |
| Ref : Pharmacol Biochem Behav , 60 :377 , 1998 |
| Abstract : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| ESTHER : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| PubMedSearch : Cheng_1998_Pharmacol.Biochem.Behav_60_377 |
| PubMedID: 9632220 |
| Title : Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats - Giovannini_1998_Eur.J.Pharmacol_354_17 |
| Author(s) : Giovannini MG , Scali C , Bartolini L , Schmidt B , Pepeu G |
| Ref : European Journal of Pharmacology , 354 :17 , 1998 |
| Abstract : Giovannini_1998_Eur.J.Pharmacol_354_17 |
| ESTHER : Giovannini_1998_Eur.J.Pharmacol_354_17 |
| PubMedSearch : Giovannini_1998_Eur.J.Pharmacol_354_17 |
| PubMedID: 9726626 |
| Title : Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells - Svensson_1998_Neuroreport_9_1519 |
| Author(s) : Svensson AL , Nordberg A |
| Ref : Neuroreport , 9 :1519 , 1998 |
| Abstract : Svensson_1998_Neuroreport_9_1519 |
| ESTHER : Svensson_1998_Neuroreport_9_1519 |
| PubMedSearch : Svensson_1998_Neuroreport_9_1519 |
| PubMedID: 9631459 |
| Title : Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease - Costagli_1998_Biochem.Pharmacol_55_1733 |
| Author(s) : Costagli C , Galli A |
| Ref : Biochemical Pharmacology , 55 :1733 , 1998 |
| Abstract : Costagli_1998_Biochem.Pharmacol_55_1733 |
| ESTHER : Costagli_1998_Biochem.Pharmacol_55_1733 |
| PubMedSearch : Costagli_1998_Biochem.Pharmacol_55_1733 |
| PubMedID: 9634011 |
| Title : Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine - Wang_1998_Eur.J.Pharmacol_349_137 |
| Author(s) : Wang T , Tang XC |
| Ref : European Journal of Pharmacology , 349 :137 , 1998 |
| Abstract : Wang_1998_Eur.J.Pharmacol_349_137 |
| ESTHER : Wang_1998_Eur.J.Pharmacol_349_137 |
| PubMedSearch : Wang_1998_Eur.J.Pharmacol_349_137 |
| PubMedID: 9671090 |
| Title : Capillary zone electrophoretic determination of some drugs against Alzheimer's disease - Vargas_1998_J.Chromatogr.A_802_121 |
| Author(s) : Vargas MG , Havel J , Patocka J |
| Ref : Journal of Chromatography A , 802 :121 , 1998 |
| Abstract : Vargas_1998_J.Chromatogr.A_802_121 |
| ESTHER : Vargas_1998_J.Chromatogr.A_802_121 |
| PubMedSearch : Vargas_1998_J.Chromatogr.A_802_121 |
| PubMedID: 9588015 |
| Title : Prevention of amitriptyline-induced avoidance impairment by tacrine in mice - Pavone_1997_Behav.Brain.Res_89_229 |
| Author(s) : Pavone F , Battaglia M , Sansone M |
| Ref : Behavioural Brain Research , 89 :229 , 1997 |
| Abstract : Pavone_1997_Behav.Brain.Res_89_229 |
| ESTHER : Pavone_1997_Behav.Brain.Res_89_229 |
| PubMedSearch : Pavone_1997_Behav.Brain.Res_89_229 |
| PubMedID: 9475630 |
| Title : Alzheimer's disease: an overview for the pharmacist - McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| Author(s) : McGuffey EC |
| Ref : J Am Pharm Assoc , 3 :347 , 1997 |
| Abstract : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| ESTHER : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| PubMedSearch : McGuffey_1997_J.Am.Pharm.Assoc_3_347 |
| PubMedID: 9170813 |
| Title : Motor dysfunction produced by tacrine administration in rats - Carriero_1997_Pharmacol.Biochem.Behav_58_851 |
| Author(s) : Carriero DL , Outslay G , Mayorga AJ , Aberman J , Gianutsos G , Salamone JD |
| Ref : Pharmacol Biochem Behav , 58 :851 , 1997 |
| Abstract : Carriero_1997_Pharmacol.Biochem.Behav_58_851 |
| ESTHER : Carriero_1997_Pharmacol.Biochem.Behav_58_851 |
| PubMedSearch : Carriero_1997_Pharmacol.Biochem.Behav_58_851 |
| PubMedID: 9408186 |
| Title : [Advantages in long-term treatment with Cognex in Alzheimer disease] - Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350 |
| Author(s) : Gracon S , Smith F , Shokry A |
| Ref : Schweiz Rundsch Med Prax , 86 :1350 , 1997 |
| Abstract : Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350 |
| ESTHER : Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350 |
| PubMedSearch : Gracon_1997_Schweiz.Rundsch.Med.Prax_86_1350 |
| PubMedID: 9381027 |
| Title : Pharmacological basis of drug therapy of Alzheimer's disease - Sharma_1997_Indian.J.Exp.Biol_35_1146 |
| Author(s) : Sharma A , Parikh V , Singh M |
| Ref : Indian J Exp Biol , 35 :1146 , 1997 |
| Abstract : Sharma_1997_Indian.J.Exp.Biol_35_1146 |
| ESTHER : Sharma_1997_Indian.J.Exp.Biol_35_1146 |
| PubMedSearch : Sharma_1997_Indian.J.Exp.Biol_35_1146 |
| PubMedID: 9567741 |
| Title : Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease - Riekkinen_1997_Neuroreport_8_1845 |
| Author(s) : Riekkinen P, Jr. , Riekkinen M , Soininen H , Kuikka J , Laakso M , Riekkinen P, Sr. |
| Ref : Neuroreport , 8 :1845 , 1997 |
| Abstract : Riekkinen_1997_Neuroreport_8_1845 |
| ESTHER : Riekkinen_1997_Neuroreport_8_1845 |
| PubMedSearch : Riekkinen_1997_Neuroreport_8_1845 |
| PubMedID: 9223063 |
| Title : The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat - Ibebunjo_1997_Anesth.Analg_85_431 |
| Author(s) : Ibebunjo C , Donati F , Fox GS , Eshelby D , Tchervenkov JI |
| Ref : Anesthesia & Analgesia , 85 :431 , 1997 |
| Abstract : Ibebunjo_1997_Anesth.Analg_85_431 |
| ESTHER : Ibebunjo_1997_Anesth.Analg_85_431 |
| PubMedSearch : Ibebunjo_1997_Anesth.Analg_85_431 |
| PubMedID: 9249126 |
| Title : Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs - Cousins_1997_Eur.J.Pharmacol_322_137 |
| Author(s) : Cousins MS , Carriero DL , Salamone JD |
| Ref : European Journal of Pharmacology , 322 :137 , 1997 |
| Abstract : Cousins_1997_Eur.J.Pharmacol_322_137 |
| ESTHER : Cousins_1997_Eur.J.Pharmacol_322_137 |
| PubMedSearch : Cousins_1997_Eur.J.Pharmacol_322_137 |
| PubMedID: 9098680 |
| Title : The effect of several putative cognition enhancers on a water maze acquisition deficit produced by pCPA + scopolamine combination treatment - Harder_1997_Pharmacol.Biochem.Behav_56_657 |
| Author(s) : Harder JA , Kelly ME |
| Ref : Pharmacol Biochem Behav , 56 :657 , 1997 |
| Abstract : Harder_1997_Pharmacol.Biochem.Behav_56_657 |
| ESTHER : Harder_1997_Pharmacol.Biochem.Behav_56_657 |
| PubMedSearch : Harder_1997_Pharmacol.Biochem.Behav_56_657 |
| PubMedID: 9130291 |
| Title : Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys - Rupniak_1997_Psychopharmacology_131_406 |
| Author(s) : Rupniak NM , Tye SJ , Field MJ |
| Ref : Psychopharmacology , 131 :406 , 1997 |
| Abstract : Rupniak_1997_Psychopharmacology_131_406 |
| ESTHER : Rupniak_1997_Psychopharmacology_131_406 |
| PubMedSearch : Rupniak_1997_Psychopharmacology_131_406 |
| PubMedID: 9226744 |
| Title : Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons - Pool_1997_Drug.Metab.Dispos_25_590 |
| Author(s) : Pool WF , Reily MD , Bjorge SM , Woolf TF |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 25 :590 , 1997 |
| Abstract : Pool_1997_Drug.Metab.Dispos_25_590 |
| ESTHER : Pool_1997_Drug.Metab.Dispos_25_590 |
| PubMedSearch : Pool_1997_Drug.Metab.Dispos_25_590 |
| PubMedID: 9152598 |
| Title : Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia [published erratum appears in Methods Find Exp Clin Pharmacol 1997 Jun\;19(5):364] - Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| Author(s) : Kojima J , Nakajima K , Ochiai M , Nakayama K |
| Ref : Methods Find Exp Clin Pharmacol , 19 :245 , 1997 |
| Abstract : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| ESTHER : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| PubMedSearch : Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245 |
| PubMedID: 9228650 |
| Title : Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) on ATP diphosphohydrolase (EC 3.6.1.5) and 5'-nucleotidase (EC 3.1.3.5) from rat brain synaptosomes - Bonan_1997_Gen.Pharmacol_28_761 |
| Author(s) : Bonan CD , Battastini AM , Schetinger MR , Moreira CM , Frassetto SS , Dias RD , Sarkis JJ |
| Ref : General Pharmacology , 28 :761 , 1997 |
| Abstract : Bonan_1997_Gen.Pharmacol_28_761 |
| ESTHER : Bonan_1997_Gen.Pharmacol_28_761 |
| PubMedSearch : Bonan_1997_Gen.Pharmacol_28_761 |
| PubMedID: 9184816 |
| Title : Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys - Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| Author(s) : Tsukada H , Kakiuchi T , Ando I , Ouchi Y |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 281 :1408 , 1997 |
| Abstract : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| ESTHER : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| PubMedSearch : Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408 |
| PubMedID: 9190877 |
| Title : Effect of tetrahydroaminoacridine, a cholinesterase inhibitor, on cognitive performance following experimental brain injury - Pike_1997_J.Neurotrauma_14_897 |
| Author(s) : Pike BR , Hamm RJ , Temple MD , Buck DL , Lyeth BG |
| Ref : Journal of Neurotrauma , 14 :897 , 1997 |
| Abstract : Pike_1997_J.Neurotrauma_14_897 |
| ESTHER : Pike_1997_J.Neurotrauma_14_897 |
| PubMedSearch : Pike_1997_J.Neurotrauma_14_897 |
| PubMedID: 9475371 |
| Title : Studies on a new series of THA analogues: effects of the aromatic residues that line the gorge of AChE - Pomponi_1997_FEBS.Lett_409_155 |
| Author(s) : Pomponi M , Marta M , Colella A , Sacchi S , Patamia M , Gatta F , Capone F , Oliverio A , Pavone F |
| Ref : FEBS Letters , 409 :155 , 1997 |
| Abstract : Pomponi_1997_FEBS.Lett_409_155 |
| ESTHER : Pomponi_1997_FEBS.Lett_409_155 |
| PubMedSearch : Pomponi_1997_FEBS.Lett_409_155 |
| PubMedID: 9202137 |
| Title : Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats - Jakala_1997_Pharmacol.Biochem.Behav_56_713 |
| Author(s) : Jakala P , Riekkinen P, Jr. |
| Ref : Pharmacol Biochem Behav , 56 :713 , 1997 |
| Abstract : Jakala_1997_Pharmacol.Biochem.Behav_56_713 |
| ESTHER : Jakala_1997_Pharmacol.Biochem.Behav_56_713 |
| PubMedSearch : Jakala_1997_Pharmacol.Biochem.Behav_56_713 |
| PubMedID: 9130298 |
| Title : Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures - Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| Author(s) : Lahiri DK , Farlow MR , Nurnberger JI, Jr. , Greig NH |
| Ref : Annals of the New York Academy of Sciences , 826 :416 , 1997 |
| Abstract : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| ESTHER : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| PubMedSearch : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| PubMedID: 9329715 |
| Title : The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations - Bezek_1996_Xenobiotica_26_935 |
| Author(s) : Bezek S , Kukan M , Pool WF , Woolf TF |
| Ref : Xenobiotica , 26 :935 , 1996 |
| Abstract : Bezek_1996_Xenobiotica_26_935 |
| ESTHER : Bezek_1996_Xenobiotica_26_935 |
| PubMedSearch : Bezek_1996_Xenobiotica_26_935 |
| PubMedID: 8893040 |
| Title : Inhibition of tacrine oral clearance by cimetidine - Forgue_1996_Clin.Pharmacol.Ther_59_444 |
| Author(s) : Forgue ST , Reece PA , Sedman AJ , deVries TM |
| Ref : Clinical Pharmacology & Therapeutics , 59 :444 , 1996 |
| Abstract : Forgue_1996_Clin.Pharmacol.Ther_59_444 |
| ESTHER : Forgue_1996_Clin.Pharmacol.Ther_59_444 |
| PubMedSearch : Forgue_1996_Clin.Pharmacol.Ther_59_444 |
| PubMedID: 8612390 |
| Title : [Alzheimer disease cannot be treated with Cognex] - |
| Author(s) : Shafazand M |
| Ref : Lakartidningen , 93 :1406 , 1996 |
| PubMedID: 8667714 |
| Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
| Ref : Molecular Pharmacology , 50 :1423 , 1996 |
| Abstract : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| ESTHER : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedID: 8967962 |
| Gene_locus related to this paper: human-BCHE |
| Title : Huperzine A, a novel promising acetylcholinesterase inhibitor - Cheng_1996_Neuroreport_8_97 |
| Author(s) : Cheng DH , Ren H , Tang XC |
| Ref : Neuroreport , 8 :97 , 1996 |
| Abstract : Cheng_1996_Neuroreport_8_97 |
| ESTHER : Cheng_1996_Neuroreport_8_97 |
| PubMedSearch : Cheng_1996_Neuroreport_8_97 |
| PubMedID: 9051760 |
| Title : Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions - Jackson_1996_Life.Sci_58_47 |
| Author(s) : Jackson JJ , Soliman MR |
| Ref : Life Sciences , 58 :47 , 1996 |
| Abstract : Jackson_1996_Life.Sci_58_47 |
| ESTHER : Jackson_1996_Life.Sci_58_47 |
| PubMedSearch : Jackson_1996_Life.Sci_58_47 |
| PubMedID: 8628110 |
| Title : Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors - Gnagey_1996_Biochem.Pharmacol_52_1767 |
| Author(s) : Gnagey AL , Ellis J |
| Ref : Biochemical Pharmacology , 52 :1767 , 1996 |
| Abstract : Gnagey_1996_Biochem.Pharmacol_52_1767 |
| ESTHER : Gnagey_1996_Biochem.Pharmacol_52_1767 |
| PubMedSearch : Gnagey_1996_Biochem.Pharmacol_52_1767 |
| PubMedID: 8986140 |
| Title : An enriched-population, double-blind, placebo-controlled, crossover study of tacrine and lecithin in Alzheimer's disease. The Tacrine 970-6 Study Group - Foster_1996_Dementia_7_260 |
| Author(s) : Foster NL , Petersen RC , Gracon SI , Lewis K |
| Ref : Dementia , 7 :260 , 1996 |
| Abstract : Foster_1996_Dementia_7_260 |
| ESTHER : Foster_1996_Dementia_7_260 |
| PubMedSearch : Foster_1996_Dementia_7_260 |
| PubMedID: 8872417 |
| Title : [New therapeutic prospects in Alzheimer disease] - Rouhart_1995_Rev.Med.Interne_16_860 |
| Author(s) : Rouhart F |
| Ref : Rev Med Interne , 16 :860 , 1995 |
| Abstract : Rouhart_1995_Rev.Med.Interne_16_860 |
| ESTHER : Rouhart_1995_Rev.Med.Interne_16_860 |
| PubMedSearch : Rouhart_1995_Rev.Med.Interne_16_860 |
| PubMedID: 8570945 |
| Title : Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library - Pirrung_1995_Chem.Biol_2_621 |
| Author(s) : Pirrung MC , Chau JH , Chen J |
| Ref : Chemistry & Biology , 2 :621 , 1995 |
| Abstract : Pirrung_1995_Chem.Biol_2_621 |
| ESTHER : Pirrung_1995_Chem.Biol_2_621 |
| PubMedSearch : Pirrung_1995_Chem.Biol_2_621 |
| PubMedID: 9383467 |
| Title : Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase - Pacheco_1995_J.Pharmacol.Exp.Ther_274_767 |
| Author(s) : Pacheco G , Palacios-Esquivel R , Moss DE |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 274 :767 , 1995 |
| Abstract : Pacheco_1995_J.Pharmacol.Exp.Ther_274_767 |
| ESTHER : Pacheco_1995_J.Pharmacol.Exp.Ther_274_767 |
| PubMedSearch : Pacheco_1995_J.Pharmacol.Exp.Ther_274_767 |
| PubMedID: 7636741 |
| Title : MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice - Murai_1994_J.Neur.Transm_98_1 |
| Author(s) : Murai S , Saito H , Abe E , Masuda Y , Odashima J , Itoh T |
| Ref : Journal of Neural Transmission General Section , 98 :1 , 1994 |
| Abstract : Murai_1994_J.Neur.Transm_98_1 |
| ESTHER : Murai_1994_J.Neur.Transm_98_1 |
| PubMedSearch : Murai_1994_J.Neur.Transm_98_1 |
| PubMedID: 7710736 |
| Title : Changes of rat blood and tissue cholinesterases following administration of tacrine derivatives in vivo - Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| Author(s) : Bajgar J , Skopec F |
| Ref : Sbornik Vedeckych Praci Lekarske Fakulty Karlovy Univerzity , 36 :73 , 1993 |
| Abstract : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| ESTHER : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| PubMedSearch : Bajgar_1993_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove_36_73 |
| PubMedID: 8165433 |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : Radic_1993_Biochemistry_32_12074 |
| ESTHER : Radic_1993_Biochemistry_32_12074 |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |
| Title : The next generation of cholinesterase inhibitors - Adem_1993_Acta.Neurol.Scand.Suppl_149_10 |
| Author(s) : Adem A |
| Ref : Acta Neurologica Scandinavica Supplementum , 149 :10 , 1993 |
| Abstract : Adem_1993_Acta.Neurol.Scand.Suppl_149_10 |
| ESTHER : Adem_1993_Acta.Neurol.Scand.Suppl_149_10 |
| PubMedSearch : Adem_1993_Acta.Neurol.Scand.Suppl_149_10 |
| PubMedID: 8128831 |
| Title : Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex - Messamore_1993_Neuropharmacol_32_745 |
| Author(s) : Messamore E , Warpman U , Ogane N , Giacobini E |
| Ref : Neuropharmacology , 32 :745 , 1993 |
| Abstract : Messamore_1993_Neuropharmacol_32_745 |
| ESTHER : Messamore_1993_Neuropharmacol_32_745 |
| PubMedSearch : Messamore_1993_Neuropharmacol_32_745 |
| PubMedID: 8413838 |
| Title : Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase - Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| Author(s) : Harel M , Schalk I , Ehret-Sabatier L , Bouet F , Goeldner M , Hirth C , Axelsen PH , Silman I , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :9031 , 1993 |
| Abstract : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| ESTHER : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| PubMedSearch : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| PubMedID: 8415649 |
| Gene_locus related to this paper: torca-ACHE |
| Title : In vitro protection of acetylcholinesterase and butyrylcholinesterase by tetrahydroaminoacridine. Comparison with physostigmine - Galli_1992_Biochem.Pharmacol_43_2427 |
| Author(s) : Galli A , Mori F , Gori I , Lucherini M |
| Ref : Biochemical Pharmacology , 43 :2427 , 1992 |
| Abstract : Galli_1992_Biochem.Pharmacol_43_2427 |
| ESTHER : Galli_1992_Biochem.Pharmacol_43_2427 |
| PubMedSearch : Galli_1992_Biochem.Pharmacol_43_2427 |
| PubMedID: 1610407 |
| Title : Preferential inhibition of acetylcholinesterase molecular forms in rat brain - Ogane_1992_Neurochem.Res_17_489 |
| Author(s) : Ogane N , Giacobini E , Messamore E |
| Ref : Neurochemical Research , 17 :489 , 1992 |
| Abstract : Ogane_1992_Neurochem.Res_17_489 |
| ESTHER : Ogane_1992_Neurochem.Res_17_489 |
| PubMedSearch : Ogane_1992_Neurochem.Res_17_489 |
| PubMedID: 1528356 |
| Title : Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and 3,4-diaminopyridine on skeletal neuromuscular transmission in vitro - Braga_1991_Br.J.Pharmacol_102_909 |
| Author(s) : Braga MF , Harvey AL , Rowan EG |
| Ref : British Journal of Pharmacology , 102 :909 , 1991 |
| Abstract : Braga_1991_Br.J.Pharmacol_102_909 |
| ESTHER : Braga_1991_Br.J.Pharmacol_102_909 |
| PubMedSearch : Braga_1991_Br.J.Pharmacol_102_909 |
| PubMedID: 1649660 |
| Title : Reversibility of the inhibition of acetylcholinesterase by tacrine - Dawson_1990_Neurosci.Lett_118_85 |
| Author(s) : Dawson RM |
| Ref : Neuroscience Letters , 118 :85 , 1990 |
| Abstract : Dawson_1990_Neurosci.Lett_118_85 |
| ESTHER : Dawson_1990_Neurosci.Lett_118_85 |
| PubMedSearch : Dawson_1990_Neurosci.Lett_118_85 |
| PubMedID: 2259472 |
| Title : The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms - Robinson_1989_Br.J.Pharmacol_98_1127 |
| Author(s) : Robinson TN , De Souza RJ , Cross AJ , Green AR |
| Ref : British Journal of Pharmacology , 98 :1127 , 1989 |
| Abstract : Robinson_1989_Br.J.Pharmacol_98_1127 |
| ESTHER : Robinson_1989_Br.J.Pharmacol_98_1127 |
| PubMedSearch : Robinson_1989_Br.J.Pharmacol_98_1127 |
| PubMedID: 2611486 |
| Title : The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro - Hunter_1989_Br.J.Pharmacol_98_79 |
| Author(s) : Hunter AJ , Murray TK , Jones JA , Cross AJ , Green AR |
| Ref : British Journal of Pharmacology , 98 :79 , 1989 |
| Abstract : Hunter_1989_Br.J.Pharmacol_98_79 |
| ESTHER : Hunter_1989_Br.J.Pharmacol_98_79 |
| PubMedSearch : Hunter_1989_Br.J.Pharmacol_98_79 |
| PubMedID: 2804555 |
| Title : Inhibitory effect of 1,2,3,4-tetrahydro-9-aminoacridine on the depolarization-induced release of GABA from cerebral cortex - de Belleroche_1988_Br.J.Pharmacol_94_1017 |
| Author(s) : de Belleroche J , Gardiner IM |
| Ref : British Journal of Pharmacology , 94 :1017 , 1988 |
| Abstract : de Belleroche_1988_Br.J.Pharmacol_94_1017 |
| ESTHER : de Belleroche_1988_Br.J.Pharmacol_94_1017 |
| PubMedSearch : de Belleroche_1988_Br.J.Pharmacol_94_1017 |
| PubMedID: 3207970 |