Sucrose-octasulfate
Sucrose octasulfate (SOS) is often used as a surrogate for heparin. Interacts with many proteins Thrombin, Fibroblast growth factors...Anti-ulcer drug
General
Type : Sulfur Compound,Glycoside
Chemical_Nomenclature : [(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfooxy-2,5-bis(sulfooxymethyl)oxolan-2-yl]oxy-3,5-disulfooxy-6-(sulfooxymethyl)oxan-4-yl] hydrogen sulfate
Canonical SMILES : C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)COS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O
InChI : InChI=1S\/C12H22O35S8\/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18\/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36)\/t4-,5-,6-,7-,8+,9-,10+,11-,12+\/m1\/s1
InChIKey : WEPNHBQBLCNOBB-UGDNZRGBSA-N
Other name(s) : Sucrosofate,Sucrose octasulfate,UNII-P7V86EYZ5L,P7V86EYZ5L,SCR,SOS
MW : 982.75
Formula : C12H22O35S8
CAS_number : 57680-56-5
PubChem : 444237
UniChem : WEPNHBQBLCNOBB-UGDNZRGBSA-N
IUPHAR :
Wikipedia :
Target
Families : Sucrose-octasulfate ligand of proteins in family: Pectinacetylesterase-Notum
Stucture :
Protein : human-NOTUM
References (1)
| Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187 |
| Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP |
| Ref : Nature , 519 :187 , 2015 |
| Abstract : Kakugawa_2015_Nature_519_187 |
| ESTHER : Kakugawa_2015_Nature_519_187 |
| PubMedSearch : Kakugawa_2015_Nature_519_187 |
| PubMedID: 25731175 |
| Gene_locus related to this paper: drome-q9vux3 , human-NOTUM |