The small ubiquitin-like protein modifier SUMO1 interacts with an armlike structure in DPP8 DPP9, leading to allosteric activation of the peptidase. SUMO1-EIL noncompetitive Inhibitor of DPP8 and DPP9 - E67 interacting loop (EIL)
Type : Peptide
Chemical_Nomenclature : SLRFLFEGQRIADNH
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : SLRFLFEGQRIADNH,E67 interacting loop (EIL),BDBM213827
Families : SUMO1-EIL ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 6TRW Crystal structure of DPP8 in complex with the EIL peptide (SLRFLFEGQRIADNH)
Protein : human-DPP8 || human-DPP9
Title : Aerosol-based ligand soaking of reservoir-free protein crystals - Ross_2021_J.Appl.Crystallogr_54_895 |
Author(s) : Ross B , Krapp S , Geiss-Friedlander R , Littmann W , Huber R , Kiefersauer R |
Ref : J Appl Crystallogr , 54 :895 , 2021 |
Abstract : Ross_2021_J.Appl.Crystallogr_54_895 |
ESTHER : Ross_2021_J.Appl.Crystallogr_54_895 |
PubMedSearch : Ross_2021_J.Appl.Crystallogr_54_895 |
PubMedID: 34188616 |
Gene_locus related to this paper: human-DPP8 |
Title : The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9 - Pilla_2013_J.Biol.Chem_288_32787 |
Author(s) : Pilla E , Kilisch M , Lenz C , Urlaub H , Geiss-Friedlander R |
Ref : Journal of Biological Chemistry , 288 :32787 , 2013 |
Abstract : Pilla_2013_J.Biol.Chem_288_32787 |
ESTHER : Pilla_2013_J.Biol.Chem_288_32787 |
PubMedSearch : Pilla_2013_J.Biol.Chem_288_32787 |
PubMedID: 24072711 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |