SR-3420
General
Type : Urea derivative,Sulfur Compound,Benzothiazepine,Azepine,Trifluoro
Chemical_Nomenclature : 1-[3-[3,5-bis(trifluoromethyl)phenyl]propyl]-3-(5-methyl-6-oxobenzo[b][1,4]benzothiazepin-3-yl)urea
Canonical SMILES : CN1C2=C(C=CC(=C2)NC(=O)NCCCC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)SC4=CC=CC=C4C1=O
InChI : InChI=1S\/C26H21F6N3O2S\/c1-35-20-14-18(8-9-22(20)38-21-7-3-2-6-19(21)23(35)36)34-24(37)33-10-4-5-15-11-16(25(27,28)29)13-17(12-15)26(30,31)32\/h2-3,6-9,11-14H,4-5,10H2,1H3,(H2,33,34,37)
InChIKey : LRQDCUNEOHFWLA-UHFFFAOYSA-N
Other name(s) : SR4995,1-(3-(3,5-bis(trifluoromethyl)phenyl)propyl)-3-(10-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4] thiazepin-8-yl)urea,SR-03000003420,SR-03000003420-1,SR-03000003420-2
MW : 553.5
Formula : C26H21F6N3O2S
CAS_number :
PubChem : 71604390
UniChem : LRQDCUNEOHFWLA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SR-3420 ligand of proteins in family: CGI-58_ABHD5_ABHD4
Stucture :
Protein : human-ABHD5 || mouse-abhd5
References (3)
| Title : ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK\/mTORC1 pathway - Chen_2020_J.Biol.Chem_296_100104 |
| Author(s) : Chen G , Zhou G , Lotvola A , Granneman JG , Wang J |
| Ref : Journal of Biological Chemistry , 296 :100104 , 2020 |
| Abstract : Chen_2020_J.Biol.Chem_296_100104 |
| ESTHER : Chen_2020_J.Biol.Chem_296_100104 |
| PubMedSearch : Chen_2020_J.Biol.Chem_296_100104 |
| PubMedID: 33219129 |
| Gene_locus related to this paper: human-ABHD5 |
| Title : Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes - Yang_2019_Nat.Metab_1_560 |
| Author(s) : Yang A , Mottillo EP , Mladenovic-Lucas L , Zhou L , Granneman JG |
| Ref : Nat Metab , 1 :560 , 2019 |
| Abstract : Yang_2019_Nat.Metab_1_560 |
| ESTHER : Yang_2019_Nat.Metab_1_560 |
| PubMedSearch : Yang_2019_Nat.Metab_1_560 |
| PubMedID: 31497752 |
| Gene_locus related to this paper: human-ABHD5 |
| Title : Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes - Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| Author(s) : Rondini EA , Mladenovic-Lucas L , Roush WR , Halvorsen GT , Green AE , Granneman JG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :367 , 2017 |
| Abstract : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| ESTHER : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedSearch : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedID: 28928121 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |