SA-57
General
Type : Carbamate,Piperidine
Chemical_Nomenclature : [2-(methylamino)-2-oxoethyl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
Canonical SMILES : CNC(=O)COC(=O)N1CCC(CC1)CCC2=CC=C(C=C2)Cl
InChI : InChI=1S\/C17H23ClN2O3\/c1-19-16(21)12-23-17(22)20-10-8-14(9-11-20)3-2-13-4-6-15(18)7-5-13\/h4-7,14H,2-3,8-12H2,1H3,(H,19,21)
InChIKey : JFSSVCSHPDLFCM-UHFFFAOYSA-N
Other name(s) : CHEMBL457918,1346169-63-8,SCHEMBL5451937,MolPort-035-765-822
MW : 338.83
Formula : C17H23ClN2O3
CAS_number :
PubChem : 44589122
UniChem : JFSSVCSHPDLFCM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : SA-57 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein : human-MGLL
References (10)
| Title : A novel inhibitor of endocannabinoid catabolic enzymes sheds light on behind the scene interplay between chronic pain, analgesic tolerance, and heroin dependence - Guindon_2017_Neuropharmacol_114_168 |
| Author(s) : Guindon J |
| Ref : Neuropharmacology , 114 :168 , 2017 |
| Abstract : Guindon_2017_Neuropharmacol_114_168 |
| ESTHER : Guindon_2017_Neuropharmacol_114_168 |
| PubMedSearch : Guindon_2017_Neuropharmacol_114_168 |
| PubMedID: 27890603 |
| Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80 |
| Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH |
| Ref : Neuropharmacology , 125 :80 , 2017 |
| Abstract : Owens_2017_Neuropharmacol_125_80 |
| ESTHER : Owens_2017_Neuropharmacol_125_80 |
| PubMedSearch : Owens_2017_Neuropharmacol_125_80 |
| PubMedID: 28673548 |
| Title : The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice - Wilkerson_2017_Neuropharmacol_114_156 |
| Author(s) : Wilkerson JL , Ghosh S , Mustafa M , Abdullah RA , Niphakis MJ , Cabrera R , Maldonado RL , Cravatt BF , Lichtman AH |
| Ref : Neuropharmacology , 114 :156 , 2017 |
| Abstract : Wilkerson_2017_Neuropharmacol_114_156 |
| ESTHER : Wilkerson_2017_Neuropharmacol_114_156 |
| PubMedSearch : Wilkerson_2017_Neuropharmacol_114_156 |
| PubMedID: 27890602 |
| Title : Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies - O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| Author(s) : O'Hearn S , Diaz P , Wan BA , DeAngelis C , Lao N , Malek L , Chow E , Blake A |
| Ref : Ann Palliat Med , 6 :S209 , 2017 |
| Abstract : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| ESTHER : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| PubMedSearch : O'Hearn_2017_Ann.Palliat.Med_6_S209 |
| PubMedID: 29156899 |
| Title : Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice - Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| Author(s) : Owens RA , Ignatowska-Jankowska B , Mustafa M , Beardsley PM , Wiley JL , Jali A , Selley DE , Niphakis MJ , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 358 :306 , 2016 |
| Abstract : Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| ESTHER : Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| PubMedSearch : Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| PubMedID: 27307500 |
| Title : Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice - Gamage_2015_Drug.Alcohol.Depend_146_7 |
| Author(s) : Gamage TF , Ignatowska-Jankowska BM , Muldoon PP , Cravatt BF , Damaj MI , Lichtman AH |
| Ref : Drug Alcohol Depend , 146 :7 , 2015 |
| Abstract : Gamage_2015_Drug.Alcohol.Depend_146_7 |
| ESTHER : Gamage_2015_Drug.Alcohol.Depend_146_7 |
| PubMedSearch : Gamage_2015_Drug.Alcohol.Depend_146_7 |
| PubMedID: 25479915 |
| Title : Delta9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice - Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| Author(s) : Wiebelhaus JM , Grim TW , Owens RA , Lazenka MF , Sim-Selley LJ , Abdullah RA , Niphakis MJ , Vann RE , Cravatt BF , Wiley JL , Negus SS , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 352 :195 , 2015 |
| Abstract : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| ESTHER : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| PubMedSearch : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| PubMedID: 25398241 |
| Title : Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Delta9-tetrahydrocannabinol in mice - Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| Author(s) : Hruba L , Seillier A , Zaki A , Cravatt BF , Lichtman AH , Giuffrida A , McMahon LR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 353 :261 , 2015 |
| Abstract : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| ESTHER : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| PubMedSearch : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| PubMedID: 25711338 |
| Title : Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice - Ramesh_2013_Neuropsychopharmacology_38_1039 |
| Author(s) : Ramesh D , Gamage TF , Vanuytsel T , Owens RA , Abdullah RA , Niphakis MJ , Shea-Donohue T , Cravatt BF , Lichtman AH |
| Ref : Neuropsychopharmacology , 38 :1039 , 2013 |
| Abstract : Ramesh_2013_Neuropsychopharmacology_38_1039 |
| ESTHER : Ramesh_2013_Neuropsychopharmacology_38_1039 |
| PubMedSearch : Ramesh_2013_Neuropsychopharmacology_38_1039 |
| PubMedID: 23303065 |
| Gene_locus related to this paper: human-MGLL |
| Title : O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors - Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| Author(s) : Niphakis MJ , Johnson DS , Ballard TE , Stiff C , Cravatt BF |
| Ref : ACS Chem Neurosci , 3 :418 , 2012 |
| Abstract : Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| ESTHER : Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| PubMedSearch : Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| PubMedID: 22860211 |
| Gene_locus related to this paper: human-MGLL |