Quinolinetrione-tacrine-Cpd3
General
Type : Quinoline,Multitarget,Derivative of Tacrine,Acridine,Alkyl linked bis-ligand,anti-Abeta-aggregation
Chemical_Nomenclature : 4-Methyl-6-((4-((1,2,3,4-tetrahydroacridin-9-yl)amino)butyl)amino)quinoline-2,5,8(1H)-trione
Canonical SMILES : C3CCC2=NC1=[C][C]=[C][C]=C1C(=C2C3)[N]CCCC[N]C4=[C]C(C5=C(C4=O)[N]C([C]=C5[C])=O)=O
InChI : InChI=1S\/C27H28N4O3\/c1-16-14-23(33)31-26-24(16)22(32)15-21(27(26)34)28-12-6-7-13-29-25-17-8-2-4-10-19(17)30-20-11-5-3-9-18(20)25\/h2,4,8,10,14-15,28H,3,5-7,9,11-13H2,1H3,(H,29,30)(H,31,33)
InChIKey : FHQBHPIXJKJNEQ-UHFFFAOYSA-N
Other name(s) :
MW : 456.54
Formula : C27H28N4O3
CAS_number :
PubChem :
UniChem : FHQBHPIXJKJNEQ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Quinolinetrione-tacrine-Cpd3 ligand of proteins in family: ACHE
Stucture :
Protein : human-ACHE
References (1)
| Title : Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease - Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| Author(s) : Uliassi E , Bergamini C , Rizzardi N , Naldi M , Cores A , Bartolini M , Carlos Menendez J , Bolognesi ML |
| Ref : Bioorganic & Medicinal Chemistry , 91 :117419 , 2023 |
| Abstract : Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| ESTHER : Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| PubMedSearch : Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| PubMedID: 37487339 |