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Inhibitor Report for: Quilostigmine

Physostigmine Eserine analogue


General
Type Derivative of physostigmine-eserine, Carbamate, Isoquinoline, Indole
Chemical_Nomenclature (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl 3,4-dihydro-2(1H)-isoquinolinecarboxylate
Canonical SMILES CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)N4CCC5=CC=CC=C5C4)C)C
InChI InChI=1S/C23H27N3O2/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26/h4-9,14,21H,10-13,15H2,1-3H3/t21-,23+/m1/s1
InChIKey IIFRKALDATVOJE-GGAORHGYSA-N
Other name(s) NXX 066 ; HP 290 ; NXX-066
________________________________________________________________________________________________
MW|377.480
Formula|C23H27N3O2
CAS_number|139314-01-5
PubChem|132228
UniChem|IIFRKALDATVOJE-GGAORHGYSA-N
IUPHAR|
Wikipedia|

Target
Families | Quilostigmine ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Quilostigmine
    Title: A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066
    Snape MF, Misra A, Murray TK, De Souza RJ, Williams JL, Cross AJ, Green AR
    Ref: Neuropharmacology, 38:181, 1999 : PubMed

            

    Title: NXX-066 in patients with Alzheimer's disease: a bridging study
    Sramek JJ, Hourani J, Jhee SS, Cutler NR
    Ref: Life Sciences, 64:1215, 1999 : PubMed

            

    Title: Detectability improvements in capillary zone electrophoresis by combining single capillary isotachophoretic preconcentration and frequency doubled argon ion laser-induced fluorescence detection
    Enlund AM, Schmidt S, Westerlund D
    Ref: Electrophoresis, 19:707, 1998 : PubMed