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Inhibitor Report for: Propargyl-Tacrine-15

balanced pharmacological profile [IC(50) (hAChE) = 1.472+/-0.024 microM; IC(50) (hBChE) = 0.659+/-0.077 microM; IC(50) (hMAO-B) = 40.39+/-5.98nM]


General
Type Multitarget, Monoamine-oxidase-inhibitor, Derivative of Tacrine, Alkyne
Chemical_Nomenclature
Canonical SMILES [C]1=[C][C]=[C]C(=[C]1)OC2=[C][C]=C3C(=[C]2)C(=C4C(=N3)CCCC4)[N]CC#[C]
InChI InChI=1S/C22H20N2O/c1-2-14-23-22-18-10-6-7-11-20(18)24-21-13-12-17(15-19(21)22)25-16-8-4-3-5-9-16/h1,3-5,8-9,12-13,15H,6-7,10-11,14H2,(H,23,24)
InChIKey IBMLQDVOCDHFMT-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|328.41
Formula|C22H20N2O
CAS_number|
PubChem|
UniChem|IBMLQDVOCDHFMT-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Propargyl-Tacrine-15 ligand of proteins in family: BCHE, ACHE
Protein | human-BCHE, human-ACHE

References:
Search PubMed for references concerning: Propargyl-Tacrine-15
    Title: Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
    Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P and Kuca K <3 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 37:2605, 2022 : PubMed