IC50 eelAChE 156.0 +/- 1.9 nM eqBuChE 82.5 +/- 0.6 nM
Type : Acridine,Derivative of Tacrine,Alkyl linked bis-ligand,Piperidine,Carboxamide
Chemical_Nomenclature : 1-(2-Chlorobenzoyl)-N-(5-((1,2,3,4-tetrahydroacridin-9-yl)amino)pentyl)piperidine-4-carboxamide
Canonical SMILES : C1N(CCC(C1)C(=O)NCCCCCNC2=C4C(=NC3=C2C=CC=C3)CCCC4)C(=O)C5=C(C=CC=C5)Cl
InChI : InChI=1S\/C31H37ClN4O2\/c32-26-13-5-2-10-23(26)31(38)36-20-16-22(17-21-36)30(37)34-19-9-1-8-18-33-29-24-11-3-6-14-27(24)35-28-15-7-4-12-25(28)29\/h2-3,5-6,10-11,13-14,22H,1,4,7-9,12,15-21H2,(H,33,35)(H,34,37)
InChIKey : ADIKRIYAGSRODZ-UHFFFAOYSA-N
Other name(s) :
MW : 533.11
Formula : C31H37ClN4O2
CAS_number :
PubChem :
UniChem : ADIKRIYAGSRODZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-ACHE || human-BCHE
Title : Multi-target potential of newly designed tacrine-derived cholinesterase inhibitors: Synthesis, computational and pharmacological study - Jevtic_2024_Bioorg.Med.Chem_101_117649 |
Author(s) : Jevtic, II , Surucic RV , Tovilovic-Kovacevic G , Zogovic N , Kostic-Rajacic SV , Andric DB , Penjisevic JZ |
Ref : Bioorganic & Medicinal Chemistry , 101 :117649 , 2024 |
Abstract : Jevtic_2024_Bioorg.Med.Chem_101_117649 |
ESTHER : Jevtic_2024_Bioorg.Med.Chem_101_117649 |
PubMedSearch : Jevtic_2024_Bioorg.Med.Chem_101_117649 |
PubMedID: 38401458 |