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Physovenine

General

Type : Carbamate,Natural,Indole,Derivative of physostigmine-eserine

Chemical_Nomenclature : 2H-Furo(2,3-b)indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)

Canonical SMILES : CC12CCOC1N(C3=C2C=C(C=C3)OC(=O)NC)C

InChI : InChI=1S\/C14H18N2O3\/c1-14-6-7-18-12(14)16(3)11-5-4-9(8-10(11)14)19-13(17)15-2\/h4-5,8,12H,6-7H2,1-3H3,(H,15,17) || InChI=1S\/C14H18N2O3\/c1-14-6-7-18-12(14)16(3)11-5-4-9(8-10(11)14)19-13(17)15-2\/h4-5,8,12H,6-7H2,1-3H3,(H,15,17)\/t12-,14-\/m0\/s1

InChIKey : LXTKNVLLWOLCOV-UHFFFAOYSA-N || LXTKNVLLWOLCOV-JSGCOSHPSA-N

Other name(s) : (-)-Physovenine,6091-05-0,3a,8-Dimethyl-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indol-5-yl methylcarbamate,2H-Furo(2,3-b)indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)-,2H-Furo[2,3-b]indol-5-ol, 3,3a,8,8a-tetrahydro-3a,8-dimethyl-, methylcarbamate (ester), (3aS-cis)-

MW : 262

Formula : C14H18N2O3

CAS_number : 6091-05-0

PubChem : 110765, 442113

UniChem : LXTKNVLLWOLCOV-UHFFFAOYSA-N || LXTKNVLLWOLCOV-JSGCOSHPSA-N

IUPHAR :

Wikipedia :

Target

Families : Physovenine ligand of proteins in family: ACHE

Stucture :

Protein :

References (5)

Title : An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine - ElAzab_2000_Org.Lett_2_2757
Author(s) : ElAzab AS , Taniguchi T , Ogasawara K
Ref : Org Lett , 2 :2757 , 2000
Abstract : ElAzab_2000_Org.Lett_2_2757
ESTHER : ElAzab_2000_Org.Lett_2_2757
PubMedSearch : ElAzab_2000_Org.Lett_2_2757
PubMedID: 10964358

Title : The role of TRP84 in catalytic power and the specificity of AChE - Pomponi_1998_Biophys.Chem_72_239
Author(s) : Pomponi M , Sacchi S , Colella A , Patamia M , Marta M
Ref : Biophysical Chemistry , 72 :239 , 1998
Abstract : Pomponi_1998_Biophys.Chem_72_239
ESTHER : Pomponi_1998_Biophys.Chem_72_239
PubMedSearch : Pomponi_1998_Biophys.Chem_72_239
PubMedID: 9691268

Title : Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease -
Author(s) : Greig NH , Pei XF , Soncrant TT , Ingram DK , Brossi A
Ref : Med Res Rev , 15 :3 , 1995
PubMedID: 7898167

Title : The synthesis and anti-acetylcholinesterase activities of (plus)-physostigmine and (plus)-physovenine -
Author(s) : Dale FJ , Robinson B
Ref : J Pharm Pharmacol , 22 :889 , 1970
PubMedID: 4395510

Title : Synthesis of dl-physovenine -
Author(s) : Longmore RB , Robinson B
Ref : Chem Ind , 29 :1297 , 1965
PubMedID: 5841772