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Inhibitor Report for: Phenyl-BDPO

TRI-O-CBESYL PHOSPHATE (TOCP) is metabolized in vitro and in vivo to form potent esterase inhibitors. CBDP and Phenyl-BDPO are potent NTE inhibitors


General
Type Organophosphate, NTE inhibitor, Cyclic OP, Not A/B H target
Chemical_Nomenclature 2-phenyl-4H-1,3,25-benzodioxaphosphinine 2-oxide
Canonical SMILES C1C2=CC=CC=C2OP(=O)(O1)C3=CC=CC=C3
InChI InChI=1S/C13H11O3P/c14-17(12-7-2-1-3-8-12)15-10-11-6-4-5-9-13(11)16-17/h1-9H,10H2
InChIKey IVVGLHFVBDTRKX-UHFFFAOYSA-N
Other name(s) K 1 (pesticide) ; BRN 2561900 ; AI3-27200 ; K-1[pesticide] ; SCHEMBL9617403 ; PBO
________________________________________________________________________________________________
MW|246.20
Formula|C13H11O3P
CAS_number|4242-21-1
PubChem|165201
UniChem|IVVGLHFVBDTRKX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Phenyl-BDPO
    Title: Potentiation and neurotoxicity induced by certain organophosphates
    Casida JE, Baron RL, Eto M, Engel JL
    Ref: Biochemical Pharmacology, 12:73, 1963 : PubMed

            

    Title: Biological activity of a tri-o-cresyl phosphate metabolite
    Casida JE, Eto M, Baron RL
    Ref: Nature, 191:1396, 1961 : PubMed