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Peganine

Derivative of Desoxypeganine from plants of the Zygophyllaceae family. Inhibits both cholinesterases and monoamine oxydases.CID 442929 CID 197084 Linarine hydrochloride CID 667496 Vasicin [German]

General

Type : Not A\/B H target,Alkaloid,Natural_modified

Chemical_Nomenclature : (R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-

Canonical SMILES : C1CN2CC3=CC=CC=C3N=C2C1O.Cl || C1CN2CC3=CC=CC=C3N=C2C1O

InChI : InChI=1S\/C11H12N2O.ClH\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\;\/h1-4,10,14H,5-7H2\;1H\/t10-\;\/m0.\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m1\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m0\/s1

InChIKey : CSDQSAHJCAKJPT-PPHPATTJSA-N || YIICVSCAKJMMDJ-SNVBAGLBSA-N || YIICVSCAKJMMDJ-JTQLQIEISA-N

Other name(s) : Vasicine,ZINC00525717,Linarine hydrochloride

MW : 188

Formula : C11H12N2O

CAS_number : 6159-55-3

PubChem : 442929, 197084, 667496

UniChem : CSDQSAHJCAKJPT-PPHPATTJSA-N || YIICVSCAKJMMDJ-SNVBAGLBSA-N || YIICVSCAKJMMDJ-JTQLQIEISA-N

IUPHAR :

Wikipedia : Vasicine

Target

Families : Peganine ligand of proteins in family: ACHE || BCHE

Stucture :

Protein :

References (4)

Title : Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo - Zhu_2018_Eur.J.Pharm.Sci_123_459
Author(s) : Zhu Y , Liu W , Qi S , Wang H , Wang Y , Deng G , Zhang Y , Li S , Ma C , Cheng X , Wang C
Ref : Eur J Pharm Sci , 123 :459 , 2018
Abstract : Zhu_2018_Eur.J.Pharm.Sci_123_459
ESTHER : Zhu_2018_Eur.J.Pharm.Sci_123_459
PubMedSearch : Zhu_2018_Eur.J.Pharm.Sci_123_459
PubMedID: 30077712

Title : In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor - Liu_2015_PLoS.One_10_e0122366
Author(s) : Liu W , Shi X , Yang Y , Cheng X , Liu Q , Han H , Yang B , He C , Wang Y , Jiang B , Wang Z , Wang C
Ref : PLoS ONE , 10 :e0122366 , 2015
Abstract : Liu_2015_PLoS.One_10_e0122366
ESTHER : Liu_2015_PLoS.One_10_e0122366
PubMedSearch : Liu_2015_PLoS.One_10_e0122366
PubMedID: 25849329

Title : Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation - Yang_2015_J.Ethnopharmacol_168_279
Author(s) : Yang Y , Cheng X , Liu W , Chou G , Wang Z , Wang C
Ref : J Ethnopharmacol , 168 :279 , 2015
Abstract : Yang_2015_J.Ethnopharmacol_168_279
ESTHER : Yang_2015_J.Ethnopharmacol_168_279
PubMedSearch : Yang_2015_J.Ethnopharmacol_168_279
PubMedID: 25862961

Title : [Pharmacological characteristics of desoxypeganine hydrochloride] - Tuliaganov_1986_Farmakol.Toksikol_49_37
Author(s) : Tuliaganov N , Sadritdinov FS , Suleimanova GA
Ref : Farmakologiia i Toksikologiia , 49 :37 , 1986
Abstract : Tuliaganov_1986_Farmakol.Toksikol_49_37
ESTHER : Tuliaganov_1986_Farmakol.Toksikol_49_37
PubMedSearch : Tuliaganov_1986_Farmakol.Toksikol_49_37
PubMedID: 3720932