Pancuronium
Myorelaxant close to Parquat || . Ligand of small conductance Ca2+-activated K+ (SKca) channels
General
Type : Nicotinic antagonist,Neuromuscular Nondepolarizing Agents,Not A\/B H target,Aminosteroid
Chemical_Nomenclature : 1,1'-[(2beta,3alpha,5alpha16beta,17beta)-3, 17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methylpiperidinium]
Canonical SMILES : CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
InChI : InChI=1S\/C35H60N2O4.2BrH\/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36\;\;\/h26-33H,7-23H2,1-6H3\;2*1H\/q+2\;\;\/p-2\/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-\;\;\/m0..\/s1
InChIKey : NPIJXCQZLFKBMV-YTGGZNJNSA-L
Other name(s) : Pavulon,pancuronium bromide
MW : 732.7
Formula : C35H60N2O4Br2
CAS_number : 15500-66-0
PubChem : 27350
UniChem : NPIJXCQZLFKBMV-YTGGZNJNSA-L
IUPHAR : 4001
Wikipedia : Pancuronium_bromide
Target
References (10)
| Title : [Profile of the effect of succinylcholine after pre-curarization with atracurium, vecuronium or pancuronium] - Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| Author(s) : Ebeling BJ , Keienburg T , Hausmann D , Apffelstaedt C |
| Ref : Anasthesiol Intensivmed Notfallmed Schmerzther , 31 :304 , 1996 |
| Abstract : Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| ESTHER : Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| PubMedSearch : Ebeling_1996_Anasthesiol.Intensivmed.Notfallmed.Schmerzther_31_304 |
| PubMedID: 8767244 |
| Title : Pretreatment with pancuronium before suxamethonium administration in patients heterozygous for the usual and the atypical plasma cholinesterase gene - Ostergaard_1991_Acta.Anaesthesiol.Scand_35_502 |
| Author(s) : Ostergaard D , Viby-Mogensen J , Hanel HK , Skovgaard LT |
| Ref : Acta Anaesthesiologica Scandinavica , 35 :502 , 1991 |
| Abstract : Ostergaard_1991_Acta.Anaesthesiol.Scand_35_502 |
| ESTHER : Ostergaard_1991_Acta.Anaesthesiol.Scand_35_502 |
| PubMedSearch : Ostergaard_1991_Acta.Anaesthesiol.Scand_35_502 |
| PubMedID: 1897345 |
| Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
| Author(s) : Lockridge O |
| Ref : Pharmacol Ther , 47 :35 , 1990 |
| Abstract : Lockridge_1990_Pharmacol.Ther_47_35 |
| ESTHER : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedID: 2195556 |
| Gene_locus related to this paper: human-BCHE |
| Title : [Inhibition of plasma cholinesterase by pancuronium and vecuronium] - Popovic_1990_Lijec.Vjesn_112_142 |
| Author(s) : Popovic L , Kunec-Vajic E |
| Ref : Lijec Vjesn , 112 :142 , 1990 |
| Abstract : Popovic_1990_Lijec.Vjesn_112_142 |
| ESTHER : Popovic_1990_Lijec.Vjesn_112_142 |
| PubMedSearch : Popovic_1990_Lijec.Vjesn_112_142 |
| PubMedID: 1978211 |
| Title : Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide - Whittaker_1981_Hum.Hered_31_242 |
| Author(s) : Whittaker M , Britten JJ |
| Ref : Hum Hered , 31 :242 , 1981 |
| Abstract : Whittaker_1981_Hum.Hered_31_242 |
| ESTHER : Whittaker_1981_Hum.Hered_31_242 |
| PubMedSearch : Whittaker_1981_Hum.Hered_31_242 |
| PubMedID: 7287015 |
| Title : Suxamethonium-induced jaw stiffness and myalgia associated with atypical cholinesterase: case report - Melvoll_1980_Can.Anaesth.Soc.J_27_283 |
| Author(s) : Melvoll R , Stovner J , Whittaker M |
| Ref : Canadian Anaesthetist's Society Journal , 27 :283 , 1980 |
| Abstract : Melvoll_1980_Can.Anaesth.Soc.J_27_283 |
| ESTHER : Melvoll_1980_Can.Anaesth.Soc.J_27_283 |
| PubMedSearch : Melvoll_1980_Can.Anaesth.Soc.J_27_283 |
| PubMedID: 7378868 |
| Title : Inhibition of the plasma cholinesterase variants by pancuronium bromide and some of its analogues - Whittaker_1980_Clin.Chim.Acta_108_89 |
| Author(s) : Whittaker M , Britten JJ |
| Ref : Clinica Chimica Acta , 108 :89 , 1980 |
| Abstract : Whittaker_1980_Clin.Chim.Acta_108_89 |
| ESTHER : Whittaker_1980_Clin.Chim.Acta_108_89 |
| PubMedSearch : Whittaker_1980_Clin.Chim.Acta_108_89 |
| PubMedID: 6108807 |
| Title : [On the inhibition of cholinesterases by pancuronium (author's transl)] - Schuh_1977_Anaesthesist_26_125 |
| Author(s) : Schuh FT |
| Ref : Anaesthesist , 26 :125 , 1977 |
| Abstract : Schuh_1977_Anaesthesist_26_125 |
| ESTHER : Schuh_1977_Anaesthesist_26_125 |
| PubMedSearch : Schuh_1977_Anaesthesist_26_125 |
| PubMedID: 855909 |
| Title : The inhibition of cholinesterases by pancuronium - Stovner_1975_Br.J.Anaesth_47_949 |
| Author(s) : Stovner J , Oftedal N , Holmboe J |
| Ref : British Journal of Anaesthesia , 47 :949 , 1975 |
| Abstract : Stovner_1975_Br.J.Anaesth_47_949 |
| ESTHER : Stovner_1975_Br.J.Anaesth_47_949 |
| PubMedSearch : Stovner_1975_Br.J.Anaesth_47_949 |
| PubMedID: 1191483 |