PE154
IC50 0.02 +/- 0.01 microM for ACHE; 0.39 +/- 0.04 microM for BCHE
General
Type : Derivative of Tacrine,Multitarget,Hydrazide,Coumarin
Chemical_Nomenclature : 2-[4-[[7-(diethylamino)-4-hydroxy-2-oxochromen-3-yl]methylideneamino]phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
Canonical SMILES : CCN(CC)C1=CC2=C(C=C1)C(=C(C(=O)O2)C=NC3=CC=C(C=C3)CC(=O)NNC4=C5CCCCC5=NC6=CC=CC=C64)O
InChI : InChI=1S\/C35H35N5O4\/c1-3-40(4-2)24-17-18-27-31(20-24)44-35(43)28(34(27)42)21-36-23-15-13-22(14-16-23)19-32(41)38-39-33-25-9-5-7-11-29(25)37-30-12-8-6-10-26(30)33\/h5,7,9,11,13-18,20-21,42H,3-4,6,8,10,12,19H2,1-2H3,(H,37,39)(H,38,41)
InChIKey : RSKDYQUBLFFWPM-UHFFFAOYSA-N
Other name(s) : PE 154,PE-154,AKOS024457971,ZINC100190239
MW : 589.7
Formula : C35H35N5O4
CAS_number : 1192750-33-6
PubChem : 135870290
UniChem : RSKDYQUBLFFWPM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : PE154 ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-ACHE || human-BCHE
References (4)
| Title : Identification of Compounds for Butyrylcholinesterase Inhibition - Li_2021_SLAS.Discov__24725552211030897 |
| Author(s) : Li S , Li AJ , Travers J , Xu T , Sakamuru S , Klumpp-Thomas C , Huang R , Xia M |
| Ref : SLAS Discov , :24725552211030897 , 2021 |
| Abstract : Li_2021_SLAS.Discov__24725552211030897 |
| ESTHER : Li_2021_SLAS.Discov__24725552211030897 |
| PubMedSearch : Li_2021_SLAS.Discov__24725552211030897 |
| PubMedID: 34269114 |
| Title : Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues - Brambilla_2011_Nanomedicine_7_521 |
| Author(s) : Brambilla D , Le Droumaguet B , Nicolas J , Hashemi SH , Wu LP , Moghimi SM , Couvreur P , Andrieux K |
| Ref : Nanomedicine , 7 :521 , 2011 |
| Abstract : Brambilla_2011_Nanomedicine_7_521 |
| ESTHER : Brambilla_2011_Nanomedicine_7_521 |
| PubMedSearch : Brambilla_2011_Nanomedicine_7_521 |
| PubMedID: 21477665 |
| Title : In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles - Hartig_2010_Eur.J.Neurosci_31_99 |
| Author(s) : Hartig W , Kacza J , Paulke BR , Grosche J , Bauer U , Hoffmann A , Elsinghorst PW , Gutschow M |
| Ref : European Journal of Neuroscience , 31 :99 , 2010 |
| Abstract : Hartig_2010_Eur.J.Neurosci_31_99 |
| ESTHER : Hartig_2010_Eur.J.Neurosci_31_99 |
| PubMedSearch : Hartig_2010_Eur.J.Neurosci_31_99 |
| PubMedID: 20092557 |
| Title : A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques - Elsinghorst_2009_Org.Biomol.Chem_7_3940 |
| Author(s) : Elsinghorst PW , Hartig W , Goldhammer S , Grosche J , Gutschow M |
| Ref : Org Biomol Chem , 7 :3940 , 2009 |
| Abstract : Elsinghorst_2009_Org.Biomol.Chem_7_3940 |
| ESTHER : Elsinghorst_2009_Org.Biomol.Chem_7_3940 |
| PubMedSearch : Elsinghorst_2009_Org.Biomol.Chem_7_3940 |
| PubMedID: 19763296 |