NP61
Dual site inhibitor active site and peripheral anionic site (PAS)
General
Type : Indole,Derivative of Tacrine,Alkyl linked bis-ligand
Chemical_Nomenclature : N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]-3-(1H-indol-3-yl)propanamide
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCCCCCNC(=O)CCC4=CNC5=CC=CC=C54
InChI : InChI=1S\/C29H33ClN4O\/c30-21-13-14-24-27(18-21)34-26-11-5-3-9-23(26)29(24)32-17-7-1-6-16-31-28(35)15-12-20-19-33-25-10-4-2-8-22(20)25\/h2,4,8,10,13-14,18-19,33H,1,3,5-7,9,11-12,15-17H2,(H,31,35)(H,32,34)
InChIKey : MZIDLDQPPBIKHJ-UHFFFAOYSA-N
Other name(s) : Indole-Tacrine Heterodimer 4,BDBM9021,CHEMBL224335,SCHEMBL1537880,N-[5(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)pentyl]-3-(1H-indol-3-yl) propionamide
MW : 489.06
Formula : C29H33ClN4O
CAS_number :
PubChem : 11167725
UniChem : MZIDLDQPPBIKHJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (3)
| Title : Potent beta-amyloid modulators - Garcia-Palomero_2008_Neurodegener.Dis_5_153 |
| Author(s) : Garcia-Palomero E , Munoz P , Usan P , Garcia P , Delgado E , de Austria C , Valenzuela R , Rubio L , Medina M , Martinez A |
| Ref : Neurodegener Dis , 5 :153 , 2008 |
| Abstract : Garcia-Palomero_2008_Neurodegener.Dis_5_153 |
| ESTHER : Garcia-Palomero_2008_Neurodegener.Dis_5_153 |
| PubMedSearch : Garcia-Palomero_2008_Neurodegener.Dis_5_153 |
| PubMedID: 18322376 |
| Title : Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD - del Monte-Millan_2006_J.Mol.Neurosci_30_85 |
| Author(s) : del Monte-Millan M , Garcia-Palomero E , Valenzuela R , Usan P , de Austria C , Munoz-Ruiz P , Rubio L , Dorronsoro I , Martinez A , Medina M |
| Ref : Journal of Molecular Neuroscience , 30 :85 , 2006 |
| Abstract : del Monte-Millan_2006_J.Mol.Neurosci_30_85 |
| ESTHER : del Monte-Millan_2006_J.Mol.Neurosci_30_85 |
| PubMedSearch : del Monte-Millan_2006_J.Mol.Neurosci_30_85 |
| PubMedID: 17192640 |
| Title : Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease - Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| Author(s) : Munoz-Ruiz P , Rubio L , Garcia-Palomero E , Dorronsoro I , del Monte-Millan M , Valenzuela R , Usan P , de Austria C , Bartolini M , Andrisano V , Bidon-Chanal A , Orozco M , Luque FJ , Medina M , Martinez A |
| Ref : Journal of Medicinal Chemistry , 48 :7223 , 2005 |
| Abstract : Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| ESTHER : Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| PubMedSearch : Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| PubMedID: 16279781 |