N-piperidinopropylgalanthamine
General
Type : Derivative of Galanthamine,Alkaloid,Natural_modified,Alkyl linked bis-ligand,Piperidine,Benzazepin,Azepine
Chemical_Nomenclature : (4aS,6R,8aS)-3-methoxy-11-(3-piperidin-1-ylpropyl)-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Canonical SMILES : COC1=C2C3=C(CN(CCC34C=CC(CC4O2)O)CCCN5CCCCC5)C=C1
InChI : InChI=1S\/C24H34N2O3\/c1-28-20-7-6-18-17-26(14-5-13-25-11-3-2-4-12-25)15-10-24-9-8-19(27)16-21(24)29-23(20)22(18)24\/h6-9,19,21,27H,2-5,10-17H2,1H3\/t19-,21-,24-\/m0\/s1
InChIKey : JIMPGPISVDHAIE-PTLVVNQVSA-N
Other name(s) : G3X,CHEMBL569978,N-Piperidinopropyl-galanthamine,SCHEMBL14626341,BDBM50303761,((4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-[3-(1-piperidinyl)propyl]-6Hbenzofuro[3a,3,2-ef][2]benzazepin-6-ol
MW : 398.54
Formula : C24H34N2O3
CAS_number :
PubChem : 9887137
UniChem : JIMPGPISVDHAIE-PTLVVNQVSA-N
IUPHAR :
Wikipedia :
Target
Families : N-piperidinopropylgalanthamine ligand of proteins in family: ACHE
Stucture : 3I6M 3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropylgalanthamine
Protein : torca-ACHE
References (1)
| Title : Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives - Bartolucci_2010_J.Med.Chem_53_745 |
| Author(s) : Bartolucci C , Haller LA , Jordis U , Fels G , Lamba D |
| Ref : Journal of Medicinal Chemistry , 53 :745 , 2010 |
| Abstract : Bartolucci_2010_J.Med.Chem_53_745 |
| ESTHER : Bartolucci_2010_J.Med.Chem_53_745 |
| PubMedSearch : Bartolucci_2010_J.Med.Chem_53_745 |
| PubMedID: 20025280 |
| Gene_locus related to this paper: torca-ACHE |