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N-octyl-tacrine

Tricyclic amine-containing compound, other alkyl derivative exist heptyl pentyl butyl (bucricaine). The CID ref here is a chloro derivative

General

Type : Derivative of Tacrine,Acridine

Chemical_Nomenclature : N-Octyl-1,2,3,4-tetrahydroacridin-9-amine

Canonical SMILES : CCCCCCCCNC1=C2CCCCC2=NC3=C1C=CC(=C3)Cl || CCCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31

InChI : InChI=1S\/C21H29ClN2\/c1-2-3-4-5-6-9-14-23-21-17-10-7-8-11-19(17)24-20-15-16(22)12-13-18(20)21\/h12-13,15H,2-11,14H2,1H3,(H,23,24) || InChI=1S\/C21H30N2\/c1-2-3-4-5-6-11-16-22-21-17-12-7-9-14-19(17)23-20-15-10-8-13-18(20)21\/h7,9,12,14H,2-6,8,10-11,13,15-16H2,1H3,(H,22,23)

InChIKey : QVWXYBWSALRXJY-UHFFFAOYSA-N || YBNDUUUQKSTMNR-UHFFFAOYSA-N

Other name(s) : THA-C8,CHEMBL2393100,N-octyl-1,2,3,4-tetrahydroacridin-9-amine,CHEMBL214225,SCHEMBL7674463,9-Acridinamine, 1,2,3,4-tetrahydro-N-octyl-

MW : 344.92 || 310.5

Formula : C21H29ClN2 || C21H30N2

CAS_number : 1440519-83-4

PubChem : 71661512, 10018304

UniChem : QVWXYBWSALRXJY-UHFFFAOYSA-N || YBNDUUUQKSTMNR-UHFFFAOYSA-N

Target

Families : N-octyl-tacrine ligand of proteins in family
ACHE

References (4)

Title : Investigation of the role of linker moieties in bifunctional tacrine hybrids - Eckroat_2013_Bioorg.Med.Chem_21_3614
Author(s) : Eckroat TJ , Green KD , Reed RA , Bornstein JJ , Garneau-Tsodikova S
Ref : Bioorganic & Medicinal Chemistry , 21 :3614 , 2013
Abstract : Eckroat_2013_Bioorg.Med.Chem_21_3614
ESTHER : Eckroat_2013_Bioorg.Med.Chem_21_3614
PubMedSearch : Eckroat_2013_Bioorg.Med.Chem_21_3614
PubMedID: 23535563

Title : The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory - Hornick_2011_Neurosci_197_280
Author(s) : Hornick A , Lieb A , Vo NP , Rollinger JM , Stuppner H , Prast H
Ref : Neuroscience , 197 :280 , 2011
Abstract : Hornick_2011_Neurosci_197_280
ESTHER : Hornick_2011_Neurosci_197_280
PubMedSearch : Hornick_2011_Neurosci_197_280
PubMedID: 21945033

Title : Search of antitubercular activities in tetrahydroacridines: synthesis and biological evaluation - Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144
Author(s) : Tripathi RP , Verma SS , Pandey J , Agarwal KC , Chaturvedi V , Manju YK , Srivastva AK , Gaikwad A , Sinha S
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5144 , 2006
Abstract : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144
ESTHER : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144
PubMedSearch : Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144
PubMedID: 16870429

Title : Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3, 4- tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice - Capone_1999_Neurobiol.Learn.Mem_71_301
Author(s) : Capone F , Oliverio A , Pomponi M , Marta M , Gatta F , Pavone F
Ref : Neurobiol Learn Mem , 71 :301 , 1999
Abstract : Capone_1999_Neurobiol.Learn.Mem_71_301
ESTHER : Capone_1999_Neurobiol.Learn.Mem_71_301
PubMedSearch : Capone_1999_Neurobiol.Learn.Mem_71_301
PubMedID: 10196108 
Array
(
    [id] => 4650
    [inhibitor] => N-octyl-tacrine
    [type] => Array
        (
            [0] => Derivative of Tacrine
            [1] => Acridine
        )

    [other_name] => Array
        (
            [0] => THA-C8
            [1] => CHEMBL2393100
            [2] => N-octyl-1,2,3,4-tetrahydroacridin-9-amine
            [3] => CHEMBL214225
            [4] => SCHEMBL7674463
            [5] => 9-Acridinamine, 1,2,3,4-tetrahydro-N-octyl-
        )

    [chemical_nomenclature] => N-Octyl-1,2,3,4-tetrahydroacridin-9-amine
    [formula] => C21H29ClN2 || C21H30N2
    [cas_number] => 1440519-83-4
    [mw] => 344.92 || 310.5
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Capone_1999_Neurobiol.Learn.Mem_71_301 || Eckroat_2013_Bioorg.Med.Chem_21_3614 || Hornick_2011_Neurosci_197_280 || Tripathi_2006_Bioorg.Med.Chem.Lett_16_5144
    [comment] => Tricyclic amine-containing compound, other alkyl derivative exist heptyl pentyl butyl (bucricaine). The CID  ref here is a chloro derivative
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 71661512 || 10018304
    [family] => ACHE
    [inchikey] => QVWXYBWSALRXJY-UHFFFAOYSA-N || YBNDUUUQKSTMNR-UHFFFAOYSA-N
    [canonicalsmiles] => CCCCCCCCNC1=C2CCCCC2=NC3=C1C=CC(=C3)Cl || CCCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31
    [inchi] => InChI=1S\/C21H29ClN2\/c1-2-3-4-5-6-9-14-23-21-17-10-7-8-11-19(17)24-20-15-16(22)12-13-18(20)21\/h12-13,15H,2-11,14H2,1H3,(H,23,24) || InChI=1S\/C21H30N2\/c1-2-3-4-5-6-11-16-22-21-17-12-7-9-14-19(17)23-20-15-10-8-13-18(20)21\/h7,9,12,14H,2-6,8,10-11,13,15-16H2,1H3,(H,22,23)
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)