Mevastatin
Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum Penicillium citinium. Mevastatin was the first statin to enter clinical trials.
General
Type : Drug,Natural,Not A\/B H target,Naphthalen,Antibiotic
Chemical_Nomenclature : [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Canonical SMILES : CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChI : InChI=1S\/C23H34O5\/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18\/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3\/t14-,15-,17+,18+,19-,20-,22-\/m0\/s1
InChIKey : AJLFOPYRIVGYMJ-INTXDZFKSA-N
Other name(s) : Mevastatin,ML-236B,Mevastatinum,Antibiotic ML 236B,Compactin (penicillium)
MW : 390.51
Formula : C23H34O5
CAS_number : 73573-88-3
PubChem : 64715
UniChem : AJLFOPYRIVGYMJ-INTXDZFKSA-N
IUPHAR :
Wikipedia : Mevastatin
Target
Families : Mevastatin ligand of proteins in family: Carboxylesterase || Carb_B_Chordata
Stucture : 1YA8 Crystal structure of human liver carboxylesterase in complex with mevastatin
Protein : human-CES1
References (2)
| Title : Mammalian carboxylesterases: from drug targets to protein therapeutics - Redinbo_2005_Drug.Discov.Today_10_313 |
| Author(s) : Redinbo MR , Potter PM |
| Ref : Drug Discov Today , 10 :313 , 2005 |
| Abstract : Redinbo_2005_Drug.Discov.Today_10_313 |
| ESTHER : Redinbo_2005_Drug.Discov.Today_10_313 |
| PubMedSearch : Redinbo_2005_Drug.Discov.Today_10_313 |
| PubMedID: 15749280 |
| Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165 |
| Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 352 :165 , 2005 |
| Abstract : Fleming_2005_J.Mol.Biol_352_165 |
| ESTHER : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedSearch : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedID: 16081098 |
| Gene_locus related to this paper: human-CES1 |