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Inhibitor Report for: Melatonin

Melatonin is a hormone produced by the pineal gland that has multiple effects including somnolence. The secretion of melatonin increases in darkness and decreases during exposure to light and is believed to play a role in regulation of the sleep-wake cycle. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors.


General
Type Derivative of Tryptamine, Indole, Not A/B H target, Natural
Chemical_Nomenclature N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChIKey DRLFMBDRBRZALE-UHFFFAOYSA-N
Other name(s) Melatonine ; N-Acetyl-5-methoxytryptamine ; Circadin ; CHEBI:16796 ; CHEMBL45 ; ZINC57060 ; DB01065
________________________________________________________________________________________________
MW|232.28
Formula|C13H16N2O2
CAS_number|73-31-4
PubChem|896
UniChem|DRLFMBDRBRZALE-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Melatonin ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 6TR5: Melatonin-human Notum complex
Protein | human-NOTUM

References:
Search PubMed for references concerning: Melatonin
    Title: Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum
    Zhao Y, Ren J, Hillier J, Jones M, Lu W, Jones EY
    Ref: J Pineal Res, :e12630, 2019 : PubMed