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Inhibitor Report for: Lipocrine

General
Type Multitarget, Derivative of Tacrine, Antioxidant, Sulfur Compound, Alkyl linked bis-ligand
Chemical_Nomenclature N-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]-5-(dithiolan-3-yl)pentanamide
Canonical SMILES C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCCCNC(=O)CCCCC4CCSS4
InChI InChI=1S/C24H32ClN3OS2/c25-17-10-11-20-22(16-17)28-21-8-3-2-7-19(21)24(20)27-14-5-13-26-23(29)9-4-1-6-18-12-15-30-31-18/h10-11,16,18H,1-9,12-15H2,(H,26,29)(H,27,28)
InChIKey QVGXTQPZHCDXRZ-UHFFFAOYSA-N
Other name(s) CHEMBL194823 ; Rac-Lipocrine ; D0F5EJ ; Tacrine-lipoic acid hybrid 7 ; SCHEMBL14341601
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MW|478.11
Formula|C24H32ClN3OS2
CAS_number|
PubChem|11375002
UniChem|QVGXTQPZHCDXRZ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Lipocrine ligand of proteins in family: ACHE
Protein | human-ACHE

References:
Search PubMed for references concerning: Lipocrine
    Title: MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond
    Bolognesi ML, Rosini M, Andrisano V, Bartolini M, Minarini A, Tumiatti V, Melchiorre C
    Ref: Curr Pharm Des, 15:601, 2009 : PubMed

            

    Title: Lipoic acid as a novel treatment for Alzheimer's disease and related dementias
    Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Munch G
    Ref: Pharmacol Ther, 113:154, 2007 : PubMed

            

    Title: Rational approach to discover multipotent anti-Alzheimer drugs
    Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C
    Ref: Journal of Medicinal Chemistry, 48:360, 2005 : PubMed