Leupeptin
Leupeptin is a protease inhibitor produced by actinomycetes, that can inhibit cysteine, serine and threonine peptidases
General
Type : Peptide,Natural
Chemical_Nomenclature : (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Canonical SMILES : CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C
InChI : InChI=1S\/C20H38N6O4\/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22\/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)\/t15-,16-,17-\/m0\/s1
InChIKey : GDBQQVLCIARPGH-ULQDDVLXSA-N
Other name(s) : N-acetyl-L-leucyl-L-leucyl-L-argininal,Leupeptin hemisulfate,Ac-Leu-Leu-Arg-H,CHEBI:6426,CHEMBL191881,Acetyl-L-leucyl-L-leucylargininal,AC1NR4EG,C01591,NK-381,SCHEMBL4669504
MW : 426.55
Formula : C20H38N6O4
CAS_number : 24365-47-7
PubChem : 72429
UniChem : GDBQQVLCIARPGH-ULQDDVLXSA-N
IUPHAR :
Wikipedia : Leupeptin
Target
References (1)
| Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249 |
| Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC |
| Ref : Journal of Biological Chemistry , 285 :39249 , 2010 |
| Abstract : McLuskey_2010_J.Biol.Chem_285_39249 |
| ESTHER : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249 |
| PubMedID: 20926390 |
| Gene_locus related to this paper: leima-OPB |