Lalistat-alkyne-probe
The ABPP probe and Lalistat also detect enzymes which are not alpha beta hydrolases: Rv1367c P9WQ95 RV2888c P9WQ99 Rv2363
General
Type : Piperidine,Lipase inhibitor,Sulfur Compound,Thiadiazol,Alkyne,ABPP-Probe
Chemical_Nomenclature : (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) 4-ethynylpiperidine-1-carboxylate
Canonical SMILES : C#CC1CCN(CC1)C(=O)OC2=NSN=C2N3CCCCC3
InChI : InChI=1S\/C15H20N4O2S\/c1-2-12-6-10-19(11-7-12)15(20)21-14-13(16-22-17-14)18-8-4-3-5-9-18\/h1,12H,3-11H2
InChIKey : VAEZZLHMRMPXQR-UHFFFAOYSA-N
Other name(s) : lalistat probe La-1,La-1,CHEMBL4104095,SCHEMBL19584717,J3.628.567B,4-Ethynyl-1-piperidinecarboxylic acid 3-(1-piperidinyl)-1,2,5-thiadiazole-4-yl ester
MW : 320.4
Formula : C15H20N4O2S
CAS_number :
PubChem : 132116679
UniChem : VAEZZLHMRMPXQR-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Lalistat-alkyne-probe ligand of proteins in family: Acidic_Lipase || 6_AlphaBeta_hydrolase || Cutinase || Hormone-sensitive_lipase_like || Monoglyceridelipase_lysophospholip
Stucture :
Protein :
References (1)
| Title : Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases - Lehmann_2016_Medchemcomm_7_1797 |
| Author(s) : Lehmann J , Vomacka J , Esser K , Nodwell M , Kolbe K , Ramer P , Protzer U , Reiling N , Sieber SA |
| Ref : Medchemcomm , 7 :1797 , 2016 |
| Abstract : Lehmann_2016_Medchemcomm_7_1797 |
| ESTHER : Lehmann_2016_Medchemcomm_7_1797 |
| PubMedSearch : Lehmann_2016_Medchemcomm_7_1797 |
| PubMedID: |
| Gene_locus related to this paper: myctu-cutas1 , myctu-lipG , myctu-RV0045C , myctu-rv0183 , myctu-RV0293C , myctu-RV0840C , myctu-Rv1191 , myctu-RV1192 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2970c , myctu-Rv3084 , myctu-YR15 , larcr-a0a0f7ir14 |